TY - JOUR
T1 - A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency
AU - Lu, Qiuhe
AU - Hitch, Thomas C.A.
AU - Zhou, Julie Y.
AU - Dwidar, Mohammed
AU - Sangwan, Naseer
AU - Lawrence, Dylan
AU - Nolan, Lila
AU - Espenschied, Scott T.
AU - Newhall, Kevin P.
AU - Han, Yi
AU - Karell, Paul E.
AU - Salazar, Vanessa
AU - Baldridge, Megan T.
AU - Clavel, Thomas
AU - Stappenbeck, Thaddeus
PY - 2024/9/27
Y1 - 2024/9/27
N2 - Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as Tomasiella immunophila, that induces and degrades IgA in the mouse intestine. Mice harboring T. immunophila are susceptible to infections and show poor mucosal repair. T. immunophila is auxotrophic for the bacterial cell wall amino sugar N-acetylmuramic acid. It delivers immunoglobulin-degrading proteases into outer membrane vesicles that preferentially degrade rodent antibodies with kappa but not lambda light chains. This work indicates a role for symbionts in immunodeficiency, which might be applicable to human disease.
AB - Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota from mice with low intestinal immunoglobulin A (IgA) levels; we identified a Gram-negative bacterium, proposed as Tomasiella immunophila, that induces and degrades IgA in the mouse intestine. Mice harboring T. immunophila are susceptible to infections and show poor mucosal repair. T. immunophila is auxotrophic for the bacterial cell wall amino sugar N-acetylmuramic acid. It delivers immunoglobulin-degrading proteases into outer membrane vesicles that preferentially degrade rodent antibodies with kappa but not lambda light chains. This work indicates a role for symbionts in immunodeficiency, which might be applicable to human disease.
UR - http://www.scopus.com/inward/record.url?scp=85205151702&partnerID=8YFLogxK
U2 - 10.1126/science.adk2536
DO - 10.1126/science.adk2536
M3 - Article
C2 - 39325906
AN - SCOPUS:85205151702
SN - 0036-8075
VL - 385
SP - eadk2536
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 6716
ER -