@article{f77984891e594fbebb4bbd6f303cc4c8,
title = "A histone methylation network regulates transgenerational epigenetic memory in C.elegans",
abstract = "How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C.elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads toinherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here, we identified multiple chromatin-modifying factors, including H3K4me1/me2 and H3K9me3 methyltransferases, an H3K9me3 demethylase, and an H3K9me reader, which either suppress or accelerate the progressive transgenerational phenotypes of spr-5 mutant worms. Our findings uncover a network of chromatin regulators that control the transgenerational flow of epigenetic information and suggest that the balance between euchromatic H3K4 and heterochromatic H3K9 methylation regulates transgenerational effects on fertility.",
author = "Greer, \{Eric L.\} and Beese-Sims, \{Sara E.\} and Emily Brookes and Ruggero Spadafora and Yun Zhu and Rothbart, \{Scott B.\} and David Aristiz{\'a}bal-Corrales and Shuzhen Chen and Badeaux, \{Aimee I.\} and Qiuye Jin and Wei Wang and Strahl, \{Brian D.\} and Colai{\'a}covo, \{Monica P.\} and Yang Shi",
note = "Funding Information: We thank T.K. Blackwell, J. Lieberman, and members of the Shi lab for discussions and critical reading of the manuscript. We thank A. Fire for discussions. We thank T. Stiernagle and the Caenorhabditis Genetics Center, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440); S. Mitani and the National Bioresource Project for the Experimental Animal “Nematode C. elegans”; and D. Moerman laboratories for C. elegans strains. E.L.G. was supported by T32-CAA009361, a Helen Hay Whitney postdoctoral fellowship, and a National Institute on Aging of the National Institute of Health (NIH) grant (K99AG043550). S.E.B.-S. was supported by an individual NRSA postdoctoral fellowship (F32GM100515) from the NIH/NIGMS, E.B. was supported in part by an EMBO Fellowship, and S.B.R. was supported by the UNC Lineberger Comprehensive Cancer Center Basic Sciences Training Program (T32CA09156) and an American Cancer Society postdoctoral fellowship (PF-13-085-01-DMC). Y.Z. and W.W. were supported in part by an NIH grant (GM096194). B.D.S. was supported in part by an NIH grant (GM068088). M.P.C. was supported by an NIH grant (GM072551), a John and Virginia Kaneb Fellowship, and a grant from the Charles E. W. Grinnell Fund. This work was supported by NIH grants to Y.S. (GM058012, CA118487, and MH096066) and an Ellison Foundation Senior Scholar Award to Y.S. Y.S. is an American Cancer Society Research Professor. Y.S. is also a cofounder of Constellation Pharmaceuticals Inc. and a member of its scientific advisory board. ",
year = "2014",
month = oct,
day = "4",
doi = "10.1016/j.celrep.2014.02.044",
language = "English",
volume = "7",
pages = "113--126",
journal = "Cell Reports",
issn = "2211-1247",
number = "1",
}