A hidden drug: Fatal Forty DDI: Diltiazem, sildenafil, CYP3A4 and sildenafil, nitroglycerin

Helga Komen; Toby N. Weingarten; Juraj Sprung

doi:10.1007/978-1-4614-7495-1_134

A hidden drug: Fatal Forty DDI: Diltiazem, sildenafil, CYP3A4 and sildenafil, nitroglycerin

Helga Komen, Toby N. Weingarten, Juraj Sprung

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This case discusses both a pharmacokinetic and a pharmacodynamic interaction between sildenafil and diltiazem. Sildenafil is a cytochrome P450 3A4 substrate. Diltiazem is a 3A4 inhibitor. In addition, the coadministration of sildenafil and diltiazem can result in severe hypotension.

Original language	English
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	605-609
Number of pages	5
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_134
State	Published - Sep 15 2015

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abstract = "This case discusses both a pharmacokinetic and a pharmacodynamic interaction between sildenafil and diltiazem. Sildenafil is a cytochrome P450 3A4 substrate. Diltiazem is a 3A4 inhibitor. In addition, the coadministration of sildenafil and diltiazem can result in severe hypotension.",

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AB - This case discusses both a pharmacokinetic and a pharmacodynamic interaction between sildenafil and diltiazem. Sildenafil is a cytochrome P450 3A4 substrate. Diltiazem is a 3A4 inhibitor. In addition, the coadministration of sildenafil and diltiazem can result in severe hypotension.

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A hidden drug: Fatal Forty DDI: Diltiazem, sildenafil, CYP3A4 and sildenafil, nitroglycerin

Abstract

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