A hidden drug: Fatal Forty DDI: Diltiazem, sildenafil, CYP3A4 and sildenafil, nitroglycerin

Helga Komen, Toby N. Weingarten, Juraj Sprung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses both a pharmacokinetic and a pharmacodynamic interaction between sildenafil and diltiazem. Sildenafil is a cytochrome P450 3A4 substrate. Diltiazem is a 3A4 inhibitor. In addition, the coadministration of sildenafil and diltiazem can result in severe hypotension.

Original languageEnglish
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages605-609
Number of pages5
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
DOIs
StatePublished - Sep 15 2015
Externally publishedYes

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    Komen, H., Weingarten, T. N., & Sprung, J. (2015). A hidden drug: Fatal Forty DDI: Diltiazem, sildenafil, CYP3A4 and sildenafil, nitroglycerin. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 605-609). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_134