A head start: Bone channels shape meningeal immunity

Jasmin Herz; Jonathan Kipnis

doi:10.1016/j.immuni.2025.12.004

A head start: Bone channels shape meningeal immunity

Research output: Contribution to journal › Comment/debate

Abstract

Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain's borders. Their work suggests that the skull is a developmental checkpoint for neuroimmune defense, potentially shaping vulnerability or resilience across the lifespan.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Immunity
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2025.12.004
State	Published - Jan 13 2026

Access to Document

10.1016/j.immuni.2025.12.004

Cite this

@article{d804fa6c5e8c4c59892eafb2c5bf8ae3,

title = "A head start: Bone channels shape meningeal immunity",

abstract = "Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain's borders. Their work suggests that the skull is a developmental checkpoint for neuroimmune defense, potentially shaping vulnerability or resilience across the lifespan.",

author = "Jasmin Herz and Jonathan Kipnis",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2026",

month = jan,

day = "13",

doi = "10.1016/j.immuni.2025.12.004",

language = "English",

volume = "59",

pages = "8--10",

journal = "Immunity",

issn = "1074-7613",

number = "1",

}

TY - JOUR

T1 - A head start

T2 - Bone channels shape meningeal immunity

AU - Herz, Jasmin

AU - Kipnis, Jonathan

PY - 2026/1/13

Y1 - 2026/1/13

N2 - Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain's borders. Their work suggests that the skull is a developmental checkpoint for neuroimmune defense, potentially shaping vulnerability or resilience across the lifespan.

AB - Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain's borders. Their work suggests that the skull is a developmental checkpoint for neuroimmune defense, potentially shaping vulnerability or resilience across the lifespan.

UR - https://www.scopus.com/pages/publications/105026654417

U2 - 10.1016/j.immuni.2025.12.004

DO - 10.1016/j.immuni.2025.12.004

M3 - Comment/debate

C2 - 41534514

AN - SCOPUS:105026654417

SN - 1074-7613

VL - 59

SP - 8

EP - 10

JO - Immunity

JF - Immunity

IS - 1

ER -

A head start: Bone channels shape meningeal immunity

Abstract

Access to Document

Other files and links

Fingerprint

Cite this