A gravity-driven droplet fluidic point-of-care test

Hamed Vahabi, Jason Liu, Yifan Dai, Daniel Y. Joh, Rhett Britton, Jacob Heggestad, David Kinnamon, Satyam Rajput, Ashutosh Chilkoti

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We report a simple droplet fluidic point-of-care test (POCT) that uses gravity to manipulate the sequence, timing, and motion of droplets on a surface. To fabricate this POCT, we first developed a surface coating toolbox of nine different coatings with three levels of wettability and three levels of slipperiness that can be independently tailored. We then fabricated a device that has interconnected fluidic elements—pumps, flow resistors, and flow guides—on a highly slippery solid surface to precisely control the timing and sequence of motion of multiple droplets and their interactions on the surface. We then used this device to carry out a multi-step enzymatic assay of a clinically relevant analyte—lactate dehydrogenase (LDH)—to demonstrate the application of this technology for point-of-care diagnosis.

Original languageEnglish
Article number100009
Issue number1
StatePublished - Jul 21 2023


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