A good turn for DNA: The structure of integration host factor bound to DNA

Tom Ellenberger; Arthur Landy

doi:10.1016/S0969-2126(97)00174-3

A good turn for DNA: The structure of integration host factor bound to DNA

Tom Ellenberger, Arthur Landy

Department of Biochemistry & Molecular Biophysics

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

The crystal structure of integration host factor (IHF) complexed with DNA shows how a small heterodimeric protein can induce a big bend in DNA. IHF exerts leverage in the minor groove and wraps DNA around the body of the protein, providing another example of sequence-specific recognition of the minor groove.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Structure
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/S0969-2126(97)00174-3
State	Published - 1997

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title = "A good turn for DNA: The structure of integration host factor bound to DNA",

abstract = "The crystal structure of integration host factor (IHF) complexed with DNA shows how a small heterodimeric protein can induce a big bend in DNA. IHF exerts leverage in the minor groove and wraps DNA around the body of the protein, providing another example of sequence-specific recognition of the minor groove.",

author = "Tom Ellenberger and Arthur Landy",

note = "Funding Information: We thank Phoebe Rice and her coworkers for supplying manuscripts and figures prior to publication. We also thank our many colleagues who make the study of DNA bending and protein–nucleic acid interactions stimulating pursuits. We gratefully acknowledge the support from the Lucille P Markey Charitable Trust (TE) and the National Institutes of Health (AL, TE). ",

year = "1997",

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T2 - The structure of integration host factor bound to DNA

AU - Ellenberger, Tom

AU - Landy, Arthur

N1 - Funding Information: We thank Phoebe Rice and her coworkers for supplying manuscripts and figures prior to publication. We also thank our many colleagues who make the study of DNA bending and protein–nucleic acid interactions stimulating pursuits. We gratefully acknowledge the support from the Lucille P Markey Charitable Trust (TE) and the National Institutes of Health (AL, TE).

PY - 1997

Y1 - 1997

N2 - The crystal structure of integration host factor (IHF) complexed with DNA shows how a small heterodimeric protein can induce a big bend in DNA. IHF exerts leverage in the minor groove and wraps DNA around the body of the protein, providing another example of sequence-specific recognition of the minor groove.

AB - The crystal structure of integration host factor (IHF) complexed with DNA shows how a small heterodimeric protein can induce a big bend in DNA. IHF exerts leverage in the minor groove and wraps DNA around the body of the protein, providing another example of sequence-specific recognition of the minor groove.

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U2 - 10.1016/S0969-2126(97)00174-3

DO - 10.1016/S0969-2126(97)00174-3

M3 - Review article

C2 - 9032076

AN - SCOPUS:0031568786

SN - 0969-2126

VL - 5

SP - 153

EP - 157

JO - Structure

JF - Structure

IS - 2

ER -

A good turn for DNA: The structure of integration host factor bound to DNA

Abstract

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