A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

COVID Human Genetic Effort

doi:10.1016/j.cell.2020.05.016

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

COVID Human Genetic Effort

Research output: Contribution to journal › Comment/debate

167 Scopus citations

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.

Original language	English
Pages (from-to)	1194-1199
Number of pages	6
Journal	Cell
Volume	181
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2020.05.016
State	Published - Jun 11 2020

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10.1016/j.cell.2020.05.016

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title = "A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection",

abstract = "SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.",

author = "{COVID Human Genetic Effort} and Casanova, {Jean Laurent} and Su, {Helen C.} and Laurent Abel and Alessandro Aiuti and Saleh Almuhsen and Arias, {Andres Augusto} and Paul Bastard and Catherine Biggs and Dusan Bogunovic and Bertrand Boisson and Stephanie Boisson-Dupuis and Alexandre Bolze and Anastasia Bondarenko and Aziz Bousfiha and Petter Brodin and Jacinta Bustamante and Manish Butte and Giorgio Casari and Michael Ciancanelli and Aurelie Cobat and Antonio Condino-Neto and Megan Cooper and Clifton Dalgard and Sara Espinosa and Hagit Feldman and Jacques Fellay and Franco, {Jose Luis} and David Hagin and Yuval Itan and Emmanuelle Jouanguy and Carrie Lucas and Davood Mansouri and Isabelle Meyts and Joshua Milner and Trine Mogensen and Tomohiro Morio and Lisa Ng and Notarangelo, {Luigi D.} and Satoshi Okada and Tayfun Ozcelik and Palac{\'i}n, {Pere Soler} and Anna Planas and Carolina Prando and Anne Puel and Aurora Pujol and Claire Redin and Laurent Renia and {Rodriguez Gallego}, {Jose Carlos} and Lluis Quintana-Murci and Vanessa Sancho-Shimizu",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

day = "11",

doi = "10.1016/j.cell.2020.05.016",

language = "English",

volume = "181",

pages = "1194--1199",

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T1 - A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

AU - COVID Human Genetic Effort

AU - Casanova, Jean Laurent

AU - Su, Helen C.

AU - Abel, Laurent

AU - Aiuti, Alessandro

AU - Almuhsen, Saleh

AU - Arias, Andres Augusto

AU - Bastard, Paul

AU - Biggs, Catherine

AU - Bogunovic, Dusan

AU - Boisson, Bertrand

AU - Boisson-Dupuis, Stephanie

AU - Bolze, Alexandre

AU - Bondarenko, Anastasia

AU - Bousfiha, Aziz

AU - Brodin, Petter

AU - Bustamante, Jacinta

AU - Butte, Manish

AU - Casari, Giorgio

AU - Ciancanelli, Michael

AU - Cobat, Aurelie

AU - Condino-Neto, Antonio

AU - Cooper, Megan

AU - Dalgard, Clifton

AU - Espinosa, Sara

AU - Feldman, Hagit

AU - Fellay, Jacques

AU - Franco, Jose Luis

AU - Hagin, David

AU - Itan, Yuval

AU - Jouanguy, Emmanuelle

AU - Lucas, Carrie

AU - Mansouri, Davood

AU - Meyts, Isabelle

AU - Milner, Joshua

AU - Mogensen, Trine

AU - Morio, Tomohiro

AU - Ng, Lisa

AU - Notarangelo, Luigi D.

AU - Okada, Satoshi

AU - Ozcelik, Tayfun

AU - Palacín, Pere Soler

AU - Planas, Anna

AU - Prando, Carolina

AU - Puel, Anne

AU - Pujol, Aurora

AU - Redin, Claire

AU - Renia, Laurent

AU - Rodriguez Gallego, Jose Carlos

AU - Quintana-Murci, Lluis

AU - Sancho-Shimizu, Vanessa

PY - 2020/6/11

Y1 - 2020/6/11

N2 - SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.

AB - SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.

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U2 - 10.1016/j.cell.2020.05.016

DO - 10.1016/j.cell.2020.05.016

M3 - Comment/debate

C2 - 32405102

AN - SCOPUS:85085371010

SN - 0092-8674

VL - 181

SP - 1194

EP - 1199

JO - Cell

JF - Cell

IS - 6

ER -

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Abstract

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