Abstract
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.
Original language | English |
---|---|
Pages (from-to) | 514-518 |
Number of pages | 5 |
Journal | Addiction Biology |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- Association
- Cannabis dependence
- Case-control
- DSM
- Genomewide
- PLINK