A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network

Dabeeru C. Rao; Michael A. Province; Mark F. Leppert; Al Oberman; Gerardo Heiss; R. Curt Ellison; Donna K. Arnett; John H. Eckfeldt; Karen Schwander; Steve C. Mockrin; Steve C. Hunt

doi:10.1016/S0895-7061(02)03247-8

A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network

Dabeeru C. Rao, Michael A. Province, Mark F. Leppert, Al Oberman, Gerardo Heiss, R. Curt Ellison, Donna K. Arnett, John H. Eckfeldt, Karen Schwander, Steve C. Mockrin, Steve C. Hunt

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.

Original language	English
Pages (from-to)	148-150
Number of pages	3
Journal	American Journal of Hypertension
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/S0895-7061(02)03247-8
State	Published - Feb 1 2003

Keywords

Genetics
Hypertension
Linkage

Access to Document

10.1016/S0895-7061(02)03247-8

Cite this

@article{6f6b22d3bbb34e2193c1f99fcf55f48f,

title = "A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network",

abstract = "Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.",

keywords = "Genetics, Hypertension, Linkage",

author = "Rao, {Dabeeru C.} and Province, {Michael A.} and Leppert, {Mark F.} and Al Oberman and Gerardo Heiss and Ellison, {R. Curt} and Arnett, {Donna K.} and Eckfeldt, {John H.} and Karen Schwander and Mockrin, {Steve C.} and Hunt, {Steve C.}",

year = "2003",

month = feb,

day = "1",

doi = "10.1016/S0895-7061(02)03247-8",

language = "English",

volume = "16",

pages = "148--150",

journal = "American Journal of Hypertension",

issn = "0895-7061",

number = "2",

}

TY - JOUR

T1 - A genome-wide affected sibpair linkage analysis of hypertension

T2 - The HyperGEN Network

AU - Rao, Dabeeru C.

AU - Province, Michael A.

AU - Leppert, Mark F.

AU - Oberman, Al

AU - Heiss, Gerardo

AU - Ellison, R. Curt

AU - Arnett, Donna K.

AU - Eckfeldt, John H.

AU - Schwander, Karen

AU - Mockrin, Steve C.

AU - Hunt, Steve C.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.

AB - Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.

KW - Genetics

KW - Hypertension

KW - Linkage

UR - http://www.scopus.com/inward/record.url?scp=12244273672&partnerID=8YFLogxK

U2 - 10.1016/S0895-7061(02)03247-8

DO - 10.1016/S0895-7061(02)03247-8

M3 - Article

C2 - 12559683

AN - SCOPUS:12244273672

SN - 0895-7061

VL - 16

SP - 148

EP - 150

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 2

ER -

A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this