Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.

Original languageEnglish
Pages (from-to)46-58
Number of pages13
JournalAmerican journal of human genetics
Issue number1
StatePublished - 1978


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