A genetic basis for human susceptibility to West Nile virus

Michael S. Diamond; Robyn S. Klein

doi:10.1016/j.tim.2006.05.004

A genetic basis for human susceptibility to West Nile virus

Michael S. Diamond
, Robyn S. Klein

Research output: Contribution to journal › Short survey › peer-review

31 Scopus citations

Abstract

West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Δ32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.

Original language	English
Pages (from-to)	287-289
Number of pages	3
Journal	Trends in Microbiology
Volume	14
Issue number	7
DOIs	https://doi.org/10.1016/j.tim.2006.05.004
State	Published - Jul 2006

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10.1016/j.tim.2006.05.004

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title = "A genetic basis for human susceptibility to West Nile virus",

abstract = "West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Δ32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.",

author = "Diamond, \{Michael S.\} and Klein, \{Robyn S.\}",

year = "2006",

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doi = "10.1016/j.tim.2006.05.004",

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T1 - A genetic basis for human susceptibility to West Nile virus

AU - Diamond, Michael S.

AU - Klein, Robyn S.

PY - 2006/7

Y1 - 2006/7

N2 - West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Δ32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.

AB - West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Δ32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.

UR - https://www.scopus.com/pages/publications/33745509649

U2 - 10.1016/j.tim.2006.05.004

DO - 10.1016/j.tim.2006.05.004

M3 - Short survey

C2 - 16750369

AN - SCOPUS:33745509649

SN - 0966-842X

VL - 14

SP - 287

EP - 289

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 7

ER -

A genetic basis for human susceptibility to West Nile virus

Abstract

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