A Generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion

Vijay Sharma, Jothilingam Sivapackiam, Scott E. Harpstrite, Julie L. Prior, Hannah Gu, Nigam P. Rath, David Piwnica-Worms

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.

Original languageEnglish
Article numbere109361
JournalPloS one
Volume9
Issue number10
DOIs
StatePublished - Oct 29 2014

Fingerprint Dive into the research topics of 'A Generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion'. Together they form a unique fingerprint.

  • Cite this

    Sharma, V., Sivapackiam, J., Harpstrite, S. E., Prior, J. L., Gu, H., Rath, N. P., & Piwnica-Worms, D. (2014). A Generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion. PloS one, 9(10), [e109361]. https://doi.org/10.1371/journal.pone.0109361