TY - JOUR
T1 - A Generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion
AU - Sharma, Vijay
AU - Sivapackiam, Jothilingam
AU - Harpstrite, Scott E.
AU - Prior, Julie L.
AU - Gu, Hannah
AU - Rath, Nigam P.
AU - Piwnica-Worms, David
N1 - Publisher Copyright:
© 2014 Varanda et al.
PY - 2014/10/29
Y1 - 2014/10/29
N2 - Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
AB - Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
UR - http://www.scopus.com/inward/record.url?scp=84908577290&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0109361
DO - 10.1371/journal.pone.0109361
M3 - Article
C2 - 25353349
AN - SCOPUS:84908577290
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 10
M1 - e109361
ER -