A generalized strategy for designing 19F/1H dual-frequency MRI coil for small animal imaging at 4.7 Tesla

Lingzhi Hu, Frank D. Hockett, Junjie Chen, Lei Zhang, Shelton D. Caruthers, Gregory M. Lanza, Samuel A. Wickline

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Purpose: To propose and test a universal strategy for building 19F/1H dual-frequency RF coil that permits multiple coil geometries. Materials and Methods: The feasibility to design 19F/1H dual-frequency RF coil based on coupled resonator model was investigated. A series capacitive matching network enables robust impedance matching for both harmonic oscillating modes of the coupled resonator. Two typical designs of 19F/1H volume coils (birdcage and saddle) at 4.7T were implemented and evaluated with electrical bench test and in vivo 19F/1H dual-nuclei imaging. Results: For various combinations of internal resistances of the sample coil and secondary resonator, numerical solutions for the tunable capacitors to optimize impedance matching were obtained using a root-seeking program. Identical and homogeneous B1 field distribution at 19F and 1H frequencies were observed in bench test and phantom image. Finally, in vivo mouse imaging confirmed the sensitivity and homogeneity of the 19F/1H dual-frequency coil design. Conclusion: A generalized strategy for designing 19F/1H dual-frequency coils based on the coupled resonator approach was developed and validated. A unique feature of this design is that it preserves the B1 field homogeneity of the RF coil at both resonant frequencies. Thus it minimizes the susceptibility effect on image co-registration.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number1
StatePublished - Jul 2011


  • coupled resonator
  • dual-frequency RF coil
  • fluorine imaging
  • molecular imaging
  • multi-nuclei MRI


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