@inproceedings{50a0d3f176984720a61aacc8fef71edb,
title = "A generalized estimating equations approach for resting-state functional MRI group analysis",
abstract = "An Alzheimer's fMRI study has motivated us to evaluate inter-regional correlations between groups. The overall objective is to assess inter-regional correlations at a resting-state with no stimulus or task. We propose using a generalized estimating equation (GEE) transition model and a GEE marginal model to model the within-subject correlation for each region. Residuals calculated from the GEE models are used to correlate brain regions and assess between group differences. The standard pooling approach of group averages of the Fisher-z transformation assuming temporal independence is a typical approach used to compare group correlations. The GEE approaches and standard Fisher-z pooling approach are demonstrated with an Alzheimer's disease (AD) connectivity study in a population of AD subjects and healthy control subjects. We also compare these methods using simulation studies and show that the transition model may have better statistical properties.",
author = "D'Angelo, {Gina M.} and Lazar, {Nicole A.} and Eddy, {William F.} and Morris, {John C.} and Sheline, {Yvette I.}",
year = "2011",
doi = "10.1109/IEMBS.2011.6091254",
language = "English",
isbn = "9781424441211",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
pages = "5064--5067",
booktitle = "33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011",
note = "33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 ; Conference date: 30-08-2011 Through 03-09-2011",
}