@inbook{05c7f00df6944096ac19ff054cb500a0,
title = "A game of numbers: The stoichiometry of antibody-mediated neutralization of flavivirus infection",
abstract = "The humoral response contributes to the protection against viral pathogens. Although antibodies have the potential to inhibit viral infections via several mechanisms, an ability to neutralize viruses directly may be particularly important. Neutralizing antibody titers are commonly used as predictors of protection from infection, especially in the context of vaccine responses and immunity. Despite the simplicity of the concept, how antibody binding results in virus inactivation is incompletely understood despite decades of research. Flaviviruses have been an attractive system in which to seek a structural and quantitative understanding of how antibody interactions with virions modulate infection because of the contribution of antibodies to both protection and pathogenesis. This review will present a stoichiometric model of antibody-mediated neutralization of flaviviruses and discuss how these concepts can inform the development of vaccines and antibody-based therapeutics.",
author = "Pierson, {Theodore C.} and Diamond, {Michael S.}",
note = "Funding Information: This work was supported by the intramural program of the National Institute of Allergy and Infectious Diseases, the Burroughs Wellcome Fund, and NIH grants R01AI073755 and R01A1089591. We apologize to those colleagues whose work we were unable to cite due to the limited scope of this review. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
doi = "10.1016/bs.pmbts.2014.10.005",
language = "English",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "141--166",
booktitle = "Progress in Molecular Biology and Translational Science",
}