A game of numbers: The stoichiometry of antibody-mediated neutralization of flavivirus infection

Theodore C. Pierson, Michael S. Diamond

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

The humoral response contributes to the protection against viral pathogens. Although antibodies have the potential to inhibit viral infections via several mechanisms, an ability to neutralize viruses directly may be particularly important. Neutralizing antibody titers are commonly used as predictors of protection from infection, especially in the context of vaccine responses and immunity. Despite the simplicity of the concept, how antibody binding results in virus inactivation is incompletely understood despite decades of research. Flaviviruses have been an attractive system in which to seek a structural and quantitative understanding of how antibody interactions with virions modulate infection because of the contribution of antibodies to both protection and pathogenesis. This review will present a stoichiometric model of antibody-mediated neutralization of flaviviruses and discuss how these concepts can inform the development of vaccines and antibody-based therapeutics.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages141-166
Number of pages26
DOIs
StatePublished - Jan 1 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume129
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

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    Pierson, T. C., & Diamond, M. S. (2015). A game of numbers: The stoichiometry of antibody-mediated neutralization of flavivirus infection. In Progress in Molecular Biology and Translational Science (pp. 141-166). (Progress in Molecular Biology and Translational Science; Vol. 129). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2014.10.005