@article{3fe0071b2ea14edf8f5042ba556dbdd6,
title = "A Galactose Dendritic Silicon (IV) Phthalocyanine as a Photosensitizing Agent in Cancer Photodynamic Therapy",
abstract = "Two protected galacto-dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal4 containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680–690 nm. The photodynamic activity of SiPcPGal4 was evaluated against UM-UC-3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal2 and SiPc(OH)2. SiPcPGal4 had a better uptake and it was a better toxicity inducer than SiPcPGal2 and SiPc(OH)2 owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles.",
keywords = "Cancer, dendrimers, galactose, photodynamic therapy, phthalocyanines",
author = "Mafalda Bispo and Pereira, {Patr{\'i}cia M.R.} and Francesca Setaro and Rodr{\'i}guez-Morgade, {M. Salom{\'e}} and Rosa Fernandes and Tom{\'a}s Torres and Tom{\'e}, {Jo{\~a}o P.C.}",
note = "Funding Information: Thanks are due to the University of Aveiro, Universidad Aut{\'o}noma de Madrid, IBILI-FMUC, Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT) for the financial support to QOPNA (FCT UID/QUI/00062/2013), IBILI (FCT UID/NEU/04539/2013) and CQE (FCT UID/QUI/0100/2013) research units, through national funds and where applicable co-financed by FEDER, within the PT2020 Partnership Agreement. Financial support from MINECO, Spain (CTQ2017-85393-P) is also acknowledged. Dr. Patr{\'i}cia M. R. Pereira (SFRH/BD/85941/2012) thanks FCT for her PhD grant. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = sep,
doi = "10.1002/cplu.201800370",
language = "English",
volume = "83",
pages = "855--860",
journal = "ChemPlusChem",
issn = "2192-6506",
number = "9",
}