A Galactose Dendritic Silicon (IV) Phthalocyanine as a Photosensitizing Agent in Cancer Photodynamic Therapy

Mafalda Bispo, Patrícia M.R. Pereira, Francesca Setaro, M. Salomé Rodríguez-Morgade, Rosa Fernandes, Tomás Torres, João P.C. Tomé

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14 Scopus citations

Abstract

Two protected galacto-dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal4 containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680–690 nm. The photodynamic activity of SiPcPGal4 was evaluated against UM-UC-3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal2 and SiPc(OH)2. SiPcPGal4 had a better uptake and it was a better toxicity inducer than SiPcPGal2 and SiPc(OH)2 owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalChemPlusChem
Volume83
Issue number9
DOIs
StatePublished - Sep 2018

Keywords

  • Cancer
  • dendrimers
  • galactose
  • photodynamic therapy
  • phthalocyanines

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