Abstract
Two protected galacto-dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal4 containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680–690 nm. The photodynamic activity of SiPcPGal4 was evaluated against UM-UC-3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal2 and SiPc(OH)2. SiPcPGal4 had a better uptake and it was a better toxicity inducer than SiPcPGal2 and SiPc(OH)2 owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles.
Original language | English |
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Pages (from-to) | 855-860 |
Number of pages | 6 |
Journal | ChemPlusChem |
Volume | 83 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2018 |
Keywords
- Cancer
- dendrimers
- galactose
- photodynamic therapy
- phthalocyanines