A functional microRNA-155 ortholog encoded by the oncogenic Marek's disease virus

Yuguang Zhao, Yongxiu Yao, Hongtao Xu, Luke Lambeth, Lorraine P. Smith, Lydia Kgosana, Xiaowei Wang, Venugopal Nair

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncogenic herpesviruses associated with distinct types of lymphomas in different species encode functional miR-155 orthologs suggested the importance of this miRNA in regulatory pathways and the biology of lymphomagenesis.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalJournal of virology
Volume83
Issue number1
DOIs
StatePublished - Jan 2009

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