A Follow-up and Family Study of Schizophrenia

Samuel B. Guze, C. Robert Cloninger, Ronald L. Martin, Paula J. Clayton

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    61 Scopus citations


    The Washington University Psychiatry Clinic, St Louis, study began with the systematic clinical evaluation of a cross section of 500 of the clinic's patients. This was followed by a “blind” follow-up of the index subjects and a blind study of first-degree relatives. This report deals with the diagnosis of schizophrenia at index, at follow-up, and among the firstdegree relatives. The results indicate that the criteria used for the diagnosis of schizophrenia select patients who show a high degree of diagnostic consistency over many years, although not all patients who meet these criteria after follow-up receive the diagnosis of schizophrenia initially. Most important, the diagnostic criteria select cases associated with a strong familial increase in the risk of schizophrenia (nearly fivefold). The follow-up results indicate also that Feighnerpositive schizophrenics often experience intercurrent depressions, but that the presence of such depressions does not affect the familial incidence of either schizophrenia or primary affective disorders.

    Original languageEnglish
    Pages (from-to)1273-1276
    Number of pages4
    JournalArchives of General Psychiatry
    Issue number12
    StatePublished - Dec 1983


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