A family of murine nk cell receptors specific for target cell mhc class i molecules

Wayne M. Yokoyama; Brian F. Daniels; William E. Seaman; Rosemarie Hunziker; David H. Margulies; Hamish R.C. Smith

doi:10.1006/smim.1995.0013

A family of murine nk cell receptors specific for target cell mhc class i molecules

Wayne M. Yokoyama, Brian F. Daniels, William E. Seaman, Rosemarie Hunziker, David H. Margulies, Hamish R.C. Smith

Research output: Contribution to journal › Article

51 Scopus citations

Abstract

The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2D^d, Ly-49A⁺NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.

Original language	English
Pages (from-to)	89-101
Number of pages	13
Journal	Seminars in immunology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1006/smim.1995.0013
State	Published - Jan 1 1995
Externally published	Yes

Keywords

C-type lectin
Ly-49
MHC class I
NK cell receptor

Access to Document

10.1006/smim.1995.0013

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Yokoyama, W. M., Daniels, B. F., Seaman, W. E., Hunziker, R., Margulies, D. H., & Smith, H. R. C. (1995). A family of murine nk cell receptors specific for target cell mhc class i molecules. Seminars in immunology, 7(2), 89-101. https://doi.org/10.1006/smim.1995.0013

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abstract = "The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.",

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AU - Yokoyama, Wayne M.

AU - Daniels, Brian F.

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AU - Margulies, David H.

AU - Smith, Hamish R.C.

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AB - The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.

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