A family of murine nk cell receptors specific for target cell mhc class i molecules

Wayne M. Yokoyama; Brian F. Daniels; William E. Seaman; Rosemarie Hunziker; David H. Margulies; Hamish R.C. Smith

doi:10.1006/smim.1995.0013

A family of murine nk cell receptors specific for target cell mhc class i molecules

Wayne M. Yokoyama, Brian F. Daniels, William E. Seaman, Rosemarie Hunziker, David H. Margulies, Hamish R.C. Smith

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2D^d, Ly-49A⁺NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.

Original language	English
Pages (from-to)	89-101
Number of pages	13
Journal	Seminars in immunology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1006/smim.1995.0013
State	Published - 1995

Keywords

C-type lectin
Ly-49
MHC class I
NK cell receptor

Access to Document

10.1006/smim.1995.0013

Cite this

@article{1bf9a1cb0490456580e50ddb1408666f,

title = "A family of murine nk cell receptors specific for target cell mhc class i molecules",

abstract = "The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.",

keywords = "C-type lectin, Ly-49, MHC class I, NK cell receptor",

author = "Yokoyama, {Wayne M.} and Daniels, {Brian F.} and Seaman, {William E.} and Rosemarie Hunziker and Margulies, {David H.} and Smith, {Hamish R.C.}",

note = "Funding Information: The authors thank our colleagues, especially Drs Franz Karlhofer, Randy Ribaudo, Megan Sykes and Jay Ryan, for their contributions to the work summarized here and for helpful discussions. We thank the members of our laboratories for their continued interest and enthusiasm. This work was supported by Howard Hughes Medical Institute grants from the NIH to WMY.",

year = "1995",

doi = "10.1006/smim.1995.0013",

language = "English",

volume = "7",

pages = "89--101",

journal = "Seminars in Immunology",

issn = "1044-5323",

number = "2",

}

TY - JOUR

T1 - A family of murine nk cell receptors specific for target cell mhc class i molecules

AU - Yokoyama, Wayne M.

AU - Daniels, Brian F.

AU - Seaman, William E.

AU - Hunziker, Rosemarie

AU - Margulies, David H.

AU - Smith, Hamish R.C.

N1 - Funding Information: The authors thank our colleagues, especially Drs Franz Karlhofer, Randy Ribaudo, Megan Sykes and Jay Ryan, for their contributions to the work summarized here and for helpful discussions. We thank the members of our laboratories for their continued interest and enthusiasm. This work was supported by Howard Hughes Medical Institute grants from the NIH to WMY.

PY - 1995

Y1 - 1995

N2 - The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.

AB - The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.

KW - C-type lectin

KW - Ly-49

KW - MHC class I

KW - NK cell receptor

UR - http://www.scopus.com/inward/record.url?scp=0029283783&partnerID=8YFLogxK

U2 - 10.1006/smim.1995.0013

DO - 10.1006/smim.1995.0013

M3 - Article

C2 - 7579199

AN - SCOPUS:0029283783

VL - 7

SP - 89

EP - 101

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 2

ER -

A family of murine nk cell receptors specific for target cell mhc class i molecules

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this