TY - JOUR
T1 - A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells
AU - Colonna, Marco
AU - Nakajima, Hideo
AU - Cella, Marina
N1 - Funding Information:
We thank Susan Giltillan and Greg Kline (Basel Institute for Immunology) for reviewing the manuscript. The Basel Institute for Immunology was founded and is supported by Hoffmann-La Roche Ltd, CH-4002 Basel.
PY - 2000/4
Y1 - 2000/4
N2 - Recently, we and others have discovered a family of receptors, called immunoglobulin (Ig)-like transcripts (ILTs), leukocyte Ig-like receptors (LIRs), or monocyte/macrophage Ig-like receptors (MIRs). ILT/LIR/MIRs are genetically, structurally and functionally related to a group of NK cell receptors for HLA class I molecules called killer cell Ig-like receptors (KIRs). Distinct ILT/LIR/MIR isotypes are differentially expressed on myeloid and lymphoid cell subsets and some of them recognize HLA class I. Whereas some isotypes inhibit others induce cell activation. Here we review what is known about their structure, distribution, biochemical and functional characteristics.
AB - Recently, we and others have discovered a family of receptors, called immunoglobulin (Ig)-like transcripts (ILTs), leukocyte Ig-like receptors (LIRs), or monocyte/macrophage Ig-like receptors (MIRs). ILT/LIR/MIRs are genetically, structurally and functionally related to a group of NK cell receptors for HLA class I molecules called killer cell Ig-like receptors (KIRs). Distinct ILT/LIR/MIR isotypes are differentially expressed on myeloid and lymphoid cell subsets and some of them recognize HLA class I. Whereas some isotypes inhibit others induce cell activation. Here we review what is known about their structure, distribution, biochemical and functional characteristics.
KW - Cell surface molecules
KW - Dendritic cells
KW - Human
KW - Immunoglobulin superfamily
KW - MHC
KW - Macrophages
KW - Monocytes
KW - Natural killer cells
UR - http://www.scopus.com/inward/record.url?scp=0034072550&partnerID=8YFLogxK
U2 - 10.1006/smim.2000.0214
DO - 10.1006/smim.2000.0214
M3 - Article
C2 - 10764620
AN - SCOPUS:0034072550
SN - 1044-5323
VL - 12
SP - 121
EP - 127
JO - Seminars in immunology
JF - Seminars in immunology
IS - 2
ER -