A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism

Howard J. Edenberg; Tatiana Foroud; Daniel L. Koller; Alison Goate; John Rice; Paul Van Eerdewegh; Theodore Reich; C. Robert Cloninger; John I. Nurnberger; Maria Kowalczuk; Bo Wu; T. K. Li; P. M. Conneally; Jay A. Tischfield; William Wu; Shantia Shears; Raymond Crowe; Victor Hesselbrock; Marc Schuckit; Bernice Porjesz; Henri Begleiter

doi:10.1111/j.1530-0277.1998.tb03680.x

A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism

Howard J. Edenberg, Tatiana Foroud, Daniel L. Koller, Alison Goate, John Rice, Paul Van Eerdewegh, Theodore Reich, C. Robert Cloninger, John I. Nurnberger, Maria Kowalczuk, Bo Wu, T. K. Li, P. M. Conneally, Jay A. Tischfield, William Wu, Shantia Shears, Raymond Crowe, Victor Hesselbrock, Marc Schuckit, Bernice PorjeszHenri Begleiter

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106 Scopus citations

Abstract

The possible association of the DRD2 locus, and in particular the Taql- A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.

Original language	English
Pages (from-to)	505-512
Number of pages	8
Journal	Alcoholism: Clinical and Experimental Research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1111/j.1530-0277.1998.tb03680.x
State	Published - 1998

Keywords

Alcoholism
Association Study
Dopamine D2 Receptor
Family Study

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Edenberg, H. J., Foroud, T., Koller, D. L., Goate, A., Rice, J., Van Eerdewegh, P., Reich, T., Cloninger, C. R., Nurnberger, J. I., Kowalczuk, M., Wu, B., Li, T. K., Conneally, P. M., Tischfield, J. A., Wu, W., Shears, S., Crowe, R., Hesselbrock, V., Schuckit, M., ... Begleiter, H. (1998). A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. Alcoholism: Clinical and Experimental Research, 22(2), 505-512. https://doi.org/10.1111/j.1530-0277.1998.tb03680.x

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title = "A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism",

abstract = "The possible association of the DRD2 locus, and in particular the Taql- A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.",

keywords = "Alcoholism, Association Study, Dopamine D2 Receptor, Family Study",

author = "Edenberg, {Howard J.} and Tatiana Foroud and Koller, {Daniel L.} and Alison Goate and John Rice and {Van Eerdewegh}, Paul and Theodore Reich and Cloninger, {C. Robert} and Nurnberger, {John I.} and Maria Kowalczuk and Bo Wu and Li, {T. K.} and Conneally, {P. M.} and Tischfield, {Jay A.} and William Wu and Shantia Shears and Raymond Crowe and Victor Hesselbrock and Marc Schuckit and Bernice Porjesz and Henri Begleiter",

year = "1998",

doi = "10.1111/j.1530-0277.1998.tb03680.x",

language = "English",

volume = "22",

pages = "505--512",

journal = "Alcoholism: Clinical and Experimental Research",

issn = "0145-6008",

number = "2",

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Edenberg, HJ, Foroud, T, Koller, DL, Goate, A, Rice, J, Van Eerdewegh, P, Reich, T, Cloninger, CR, Nurnberger, JI, Kowalczuk, M, Wu, B, Li, TK, Conneally, PM, Tischfield, JA, Wu, W, Shears, S, Crowe, R, Hesselbrock, V, Schuckit, M, Porjesz, B & Begleiter, H 1998, 'A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism', Alcoholism: Clinical and Experimental Research, vol. 22, no. 2, pp. 505-512. https://doi.org/10.1111/j.1530-0277.1998.tb03680.x

TY - JOUR

T1 - A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism

AU - Edenberg, Howard J.

AU - Foroud, Tatiana

AU - Koller, Daniel L.

AU - Goate, Alison

AU - Rice, John

AU - Van Eerdewegh, Paul

AU - Reich, Theodore

AU - Cloninger, C. Robert

AU - Nurnberger, John I.

AU - Kowalczuk, Maria

AU - Wu, Bo

AU - Li, T. K.

AU - Conneally, P. M.

AU - Tischfield, Jay A.

AU - Wu, William

AU - Shears, Shantia

AU - Crowe, Raymond

AU - Hesselbrock, Victor

AU - Schuckit, Marc

AU - Porjesz, Bernice

AU - Begleiter, Henri

PY - 1998

Y1 - 1998

N2 - The possible association of the DRD2 locus, and in particular the Taql- A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.

AB - The possible association of the DRD2 locus, and in particular the Taql- A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.

KW - Alcoholism

KW - Association Study

KW - Dopamine D2 Receptor

KW - Family Study

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U2 - 10.1111/j.1530-0277.1998.tb03680.x

DO - 10.1111/j.1530-0277.1998.tb03680.x

M3 - Article

C2 - 9581660

AN - SCOPUS:0031970864

SN - 0145-6008

VL - 22

SP - 505

EP - 512

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

IS - 2

ER -

A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism

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