A facile synthesis of highly water-soluble, core-shell organo-silica nanoparticles with controllable size via sol-gel process

Hongwei Du, Paul D. Hamilton, Matthew A. Reilly, André d'Avignon, Pramit Biswas, Nathan Ravi

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

A series of highly water-soluble organo-silica nanoparticles, ranging from 2 to 10 nm in diameter, were synthesized by the cohydrolysis and copolycondensation reactions. ω-methoxy(polyethyleneoxy)propyltrimethoxysilane (PEG6-9) and hydroxymethyltriethoxysilane (HMTEOS) mixtures were catalyzed by sodium hydroxide in the presence of surfactant benzethonium chloride (BTC) with various ratios of PEG6-9/HMTEOS at room temperature. The synthesized organo-silica nanoparticles possess a core-shell structure with a core of organo-silica resulting from HMTEOS and a monolayer shell of PEG6-9. The chemo-physical characteristics of the particles were studied by gel permeation chromatography (GPC), Fourier transform infrared (FTIR) spectroscopy, 29Si nuclear magnetic resonance (NMR), dynamic light scattering (DLS), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). The molecular weight and particle size of the particles increased with increasing HMTEOS molar ratios. The richest HMTEOS composition for the water-soluble particles was found to be HMTEOS:PEG6-9 = 80:20, where the particles had a 6 nm diameter core and a 0.8 nm thick shell. We propose that these water-soluble organo-silica nanoparticles will be suitable for biomedical applications.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalJournal of Colloid and Interface Science
Volume340
Issue number2
DOIs
StatePublished - Dec 15 2009

Keywords

  • Core-shell
  • Nanoparticles
  • Organic silica
  • Sol-gel
  • Water-soluble

Fingerprint

Dive into the research topics of 'A facile synthesis of highly water-soluble, core-shell organo-silica nanoparticles with controllable size via sol-gel process'. Together they form a unique fingerprint.

Cite this