A dual-targeting nanocarrier based on modified chitosan micelles for tumor imaging and therapy

Haiyan Chen, Yuqi Chen, Haibo Yang, Weixia Xu, Min Zhang, Yuxiang Ma, Samuel Achilefu, Yueqing Gu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Conventional chemotherapy suffers from non-specificity, lack of aqueous solubility and multidrug resistance. Tumor-targeting nanotherapeutics exhibit unique advantages in the delivery of drugs specifically into tumors. Here, folic acid (FA), methionine (Met) and a near infrared (NIR) fluorescence probe (cypate, ICG derivative) were all bio-conjugated to succinyl-chitosan (SC) micelles. An anti-cancer drug (paclitaxel, PTX) was loaded into the hydrophobic cores of the formed FA-Met-SC-ICG derivative (FMSCI) micelles, which were under 200 nm in size. In comparison with micelles containing a single targeting moiety (FA or Met), FA and Met co-mediated micelles presented excellent biocompatibility, much higher affinity for cancer cells and excellent tumor-specific distribution in tumor-bearing mice. In vivo anti-tumor activity demonstrated that PTX-loaded FMSCI provided favourable therapeutic efficacy for tumors. In this research, novel nanotherapeutics based on FMSCI loaded with an anti-cancer drug provide a promising nanocomposite for combined tumor-targeting imaging and therapy.

Original languageEnglish
Pages (from-to)4734-4746
Number of pages13
JournalPolymer Chemistry
Volume5
Issue number16
DOIs
StatePublished - Aug 21 2014

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