A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

Bradley R. Miller; Craig Press; Richard W. Daniels; Yo Sasaki; Jeffrey Milbrandt; Aaron Diantonio

doi:10.1038/nn.2290

A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

Bradley R. Miller, Craig Press, Richard W. Daniels, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio

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239 Scopus citations

Abstract

Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.

Original language	English
Pages (from-to)	387-389
Number of pages	3
Journal	Nature neuroscience
Volume	12
Issue number	4
DOIs	https://doi.org/10.1038/nn.2290
State	Published - Apr 2009

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abstract = "Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.",

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AU - Diantonio, Aaron

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A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

Abstract

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