A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2

Alexandra Sommer; Rainer Rickert; Peter Fischer; Hans Steinhart; Rolf D. Walter; Eva Liebau

doi:10.1128/IAI.71.6.3603-3606.2003

A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D₂

Alexandra Sommer, Rainer Rickert, Peter Fischer, Hans Steinhart, Rolf D. Walter, Eva Liebau

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D₂ directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.

Original language	English
Pages (from-to)	3603-3606
Number of pages	4
Journal	Infection and immunity
Volume	71
Issue number	6
DOIs	https://doi.org/10.1128/IAI.71.6.3603-3606.2003
State	Published - Jun 1 2003

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title = "A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2",

abstract = "The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D2 directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.",

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T1 - A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2

AU - Sommer, Alexandra

AU - Rickert, Rainer

AU - Fischer, Peter

AU - Steinhart, Hans

AU - Walter, Rolf D.

AU - Liebau, Eva

PY - 2003/6/1

Y1 - 2003/6/1

N2 - The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D2 directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.

AB - The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D2 directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.

UR - http://www.scopus.com/inward/record.url?scp=0038103816&partnerID=8YFLogxK

U2 - 10.1128/IAI.71.6.3603-3606.2003

DO - 10.1128/IAI.71.6.3603-3606.2003

M3 - Article

C2 - 12761146

AN - SCOPUS:0038103816

VL - 71

SP - 3603

EP - 3606

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 6

ER -

A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D₂

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