A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2

Alexandra Sommer, Rainer Rickert, Peter Fischer, Hans Steinhart, Rolf D. Walter, Eva Liebau

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D2 directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.

Original languageEnglish
Pages (from-to)3603-3606
Number of pages4
JournalInfection and immunity
Volume71
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Dive into the research topics of 'A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D<sub>2</sub>'. Together they form a unique fingerprint.

Cite this