Abstract
The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D2 directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.
Original language | English |
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Pages (from-to) | 3603-3606 |
Number of pages | 4 |
Journal | Infection and immunity |
Volume | 71 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2003 |