A direct comparison between lamellar body counts and fluorescent polarization methods for predicting respiratory distress syndrome

Shannon Haymond, Veronica I. Luzzi, Curtis A. Parvin, Ann M. Gronowski

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Our objective was to directly compare the diagnostic usefulness of lamellar body counting (LBC) and the TDx-FLM II assay (Abbott Laboratories, Abbott Park, IL) for predicting respiratory distress syndrome (RDS). This was a 5-year, retrospective, cohort study. A diagnosis of RDS was given to infants who received surfactant treatment and/or required ventilator support and/or continuous positive airway pressure for more than 24 hours. There were 172 infants without RDS and 12 with RDS included in the study. By using a TDx-FLM II cutoff of 55 mg/g or more for maturity, the sensitivity was 83%, specificity was 65%, predictive value of a mature result was 98%, and predictive value of an immature result was 14%. These results were similar to LBC using a cutoff of 50,000/μL or more with sensitivity of 92%, a specificity of 60%, a predictive value of a mature result of 99%, and a predictive value of an immature result of 14%. The LBC and TDx-FLM II methods have similar clinical usefulness.

Original languageEnglish
Pages (from-to)894-899
Number of pages6
JournalAmerican journal of clinical pathology
Volume126
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • Fetal lung maturity
  • Fluorescent polarization
  • Lamellar body counts

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