A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome

Keyphrases

• Mouse Model 100%
• LAMB2 100%
• Nephrotic Syndrome 100%
• Laminin-2 100%
• Laminin 50%
• Proteinuria 50%
• Glomerular Basement Membrane 50%
• Pierson Syndrome 50%
• Foot Process 33%
• Type IV Collagen 33%
• Albuminuria 33%
• Missense mutation 33%
• Null Mice 16%
• Cas9 Protein 16%
• Creatinine 16%
• Severe Disease 16%
• Glomerular Filtration 16%
• N-terminal Domain 16%
• Foot Process Effacement 16%
• Podocyte 16%
• Delay Effects 16%
• Heterotrimer 16%
• Alport Syndrome 16%
• Blood Urea Nitrogen 16%
• Interstitial Fibrosis 16%
• Mild Forms 16%
• Glomerulosclerosis 16%
• Effacement 16%
• Chronic Model 16%
• Plateaued 16%
• Nidogen-1 16%
• Preserved Renal Function 16%
• Permselectivity 16%
• Glomerular Basement Membrane Thickening 16%
• Podocyte Foot Process Effacement 16%
• Amino Acid Deletion 16%
• Membrane Destabilization 16%
• Filtration Mechanism 16%

Biochemistry, Genetics and Molecular Biology

• Mouse Model 100%
• N-Terminus 100%
• Laminin 100%
• Glomerulus Basement Membrane 80%
• Podocyte 40%
• Type IV Collagen 40%
• Missense Mutation 40%
• Knockout Mouse 20%
• CRISPR/Cas9 20%
• Amino Acids 20%
• Kidney Function 20%
• Glomerulus Filtration 20%
• Blood Urea Nitrogen 20%
• Entactin 20%
• Creatinine 20%