A decade in review after idiopathic scoliosis was first called a complex trait—a tribe to the late Dr. Yves Cotrel for his support in studies of etiology of scoliosis

Nelson L.S. Tang, Matthew B. Dobbs, Christina A. Gurnett, Yong Qiu, T. P. Lam, Jack C.Y. Cheng, Nancy Hadley-Miller

Research output: Contribution to journalReview articlepeer-review

Abstract

Adolescent Idiopathic Scoliosis (AIS) is a prevalent and important spine disorder in the pediatric age group. An increased family tendency was observed for a long time, but the underlying genetic mechanism was uncertain. In 1999, Dr. Yves Cotrel founded the Cotrel Foundation in the Institut de France, which supported collaboration of international researchers to work together to better understand the etiology of AIS. This new concept of AIS as a complex trait evolved in this setting among researchers who joined the annual Cotrel meetings. It is now over a decade since the first proposal of the complex trait genetic model for AIS. Here, we review in detail the vast information about the genetic and environmental factors in AIS pathogenesis gathered to date. More importantly, new insights into AIS etiology were brought to us through new research data under the perspective of a complex trait. Hopefully, future research directions may lead to better management of AIS, which has a tremendous impact on affected adolescents in terms of both physical growth and psychological development.

Original languageEnglish
Article number1033
JournalGenes
Volume12
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • Complex trait
  • Genetic linkage study
  • Genetic predisposition
  • Genome wide association study
  • Idiopathic scoliosis
  • Model animal

Fingerprint

Dive into the research topics of 'A decade in review after idiopathic scoliosis was first called a complex trait—a tribe to the late Dr. Yves Cotrel for his support in studies of etiology of scoliosis'. Together they form a unique fingerprint.

Cite this