A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes

Stephanie S. Cabler, Anthony R. French, Anthony Orvedahl

Research output: Contribution to journalReview articlepeer-review

Abstract

An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a ‘cytokine storm syndrome’ (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.

Original languageEnglish
Pages (from-to)1078-1085
Number of pages8
JournalTrends in Molecular Medicine
Volume26
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • COVID-19;cytokine storm syndrome
  • inflammation
  • multisystem inflammatory syndrome in children
  • severe acute respiratory syndrome coronavirus 2
  • virology

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