TY - JOUR
T1 - A Cytokine Circus with a Viral Ringleader
T2 - SARS-CoV-2-Associated Cytokine Storm Syndromes
AU - Cabler, Stephanie S.
AU - French, Anthony R.
AU - Orvedahl, Anthony
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/12
Y1 - 2020/12
N2 - An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a ‘cytokine storm syndrome’ (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.
AB - An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a ‘cytokine storm syndrome’ (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.
KW - COVID-19;cytokine storm syndrome
KW - inflammation
KW - multisystem inflammatory syndrome in children
KW - severe acute respiratory syndrome coronavirus 2
KW - virology
UR - http://www.scopus.com/inward/record.url?scp=85092517589&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2020.09.012
DO - 10.1016/j.molmed.2020.09.012
M3 - Review article
C2 - 33051104
AN - SCOPUS:85092517589
SN - 1471-4914
VL - 26
SP - 1078
EP - 1085
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 12
ER -