A cryptic pocket in Ebola VP35 allosterically controls RNA binding

Keyphrases

• RNA Binding 100%
• Cryptic Pocket 100%
• Ebola 100%
• Double-stranded RNA 50%
• Interferon-α (IFN-α) 25%
• Drug Target 25%
• Immune Evasion 25%
• Covalent Modification 25%
• Protein-nucleic Acid Interactions 25%
• Drug Design 25%
• Machine Learning Algorithms 25%
• Thiol Labeling 25%
• Labeling Experiment 25%
• Replication Cycle 25%
• Allostery 25%
• Binding Interface 25%
• Drug Binding 25%
• Simulation-based Learning 25%
• Network Support 25%
• Sampling Device 25%
• Druggable Pockets 25%
• Adaptive Sampling 25%
• Sampling Simulation 25%
• Allosteric Network 25%

Biochemistry, Genetics and Molecular Biology

• RNA Binding 100%
• Double-Stranded RNA 100%
• Immune Evasion 50%
• Protein Nucleic Acid Interaction 50%
• Allosteric Regulation 50%
• Drug Binding 50%
• Interferon 50%
• Thiol 50%