A crowdsourcing evaluation of the NIH chemical probes

Tudor I. Oprea; Cristian G. Bologa; Scott Boyer; Ramona F. Curpan; Robert C. Glen; Andrew L. Hopkins; Christopher A. Lipinski; Garland R. Marshall; Yvonne C. Martin; Liliana Ostopovici-Halip; Gilbert Rishton; Oleg Ursu; Roy J. Vaz; Chris Waller; Herbert Waldmann; Larry A. Sklar

doi:10.1038/nchembio0709-441

A crowdsourcing evaluation of the NIH chemical probes

Tudor I. Oprea
, Cristian G. Bologa
, Scott Boyer
, Ramona F. Curpan
, Robert C. Glen
, Andrew L. Hopkins
, Christopher A. Lipinski
, Garland R. Marshall
, Yvonne C. Martin
, Liliana Ostopovici-Halip
, Gilbert Rishton
, Oleg Ursu
, Roy J. Vaz
, Chris Waller
, Herbert Waldmann
, Larry A. Sklar

Research output: Contribution to journal › Comment/debate

106 Scopus citations

Abstract

Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Nature Chemical Biology
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/nchembio0709-441
State	Published - Jul 2009

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Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H., & Sklar, L. A. (2009). A crowdsourcing evaluation of the NIH chemical probes. Nature Chemical Biology, 5(7), 441-447. https://doi.org/10.1038/nchembio0709-441

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title = "A crowdsourcing evaluation of the NIH chemical probes",

abstract = "Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.",

author = "Oprea, \{Tudor I.\} and Bologa, \{Cristian G.\} and Scott Boyer and Curpan, \{Ramona F.\} and Glen, \{Robert C.\} and Hopkins, \{Andrew L.\} and Lipinski, \{Christopher A.\} and Marshall, \{Garland R.\} and Martin, \{Yvonne C.\} and Liliana Ostopovici-Halip and Gilbert Rishton and Oleg Ursu and Vaz, \{Roy J.\} and Chris Waller and Herbert Waldmann and Sklar, \{Larry A.\}",

note = "Funding Information: We thank E. Bolton (NIH/PubChem) for promptly answering questions related to the MLI. B.K. Shoichet (University of California, San Francisco) voted on some of these chemical probes, as reflected in Figure 1 and Supplementary Table 1. C.A. Taylor, J. Feng, R. Yang, Y. Tang, D. Kuster and C.M.W. Ho (all from Washington University School of Medicine) contributed to the probe evaluation vote of G. Marshall. J. Besnard (University of Dundee) contributed to the vote of A. Hopkins. This work was supported by NIH grant 1U54MH084690 (to the University of New Mexico).",

year = "2009",

month = jul,

doi = "10.1038/nchembio0709-441",

language = "English",

volume = "5",

pages = "441--447",

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AU - Oprea, Tudor I.

AU - Bologa, Cristian G.

AU - Boyer, Scott

AU - Curpan, Ramona F.

AU - Glen, Robert C.

AU - Hopkins, Andrew L.

AU - Lipinski, Christopher A.

AU - Marshall, Garland R.

AU - Martin, Yvonne C.

AU - Ostopovici-Halip, Liliana

AU - Rishton, Gilbert

AU - Ursu, Oleg

AU - Vaz, Roy J.

AU - Waller, Chris

AU - Waldmann, Herbert

AU - Sklar, Larry A.

N1 - Funding Information: We thank E. Bolton (NIH/PubChem) for promptly answering questions related to the MLI. B.K. Shoichet (University of California, San Francisco) voted on some of these chemical probes, as reflected in Figure 1 and Supplementary Table 1. C.A. Taylor, J. Feng, R. Yang, Y. Tang, D. Kuster and C.M.W. Ho (all from Washington University School of Medicine) contributed to the probe evaluation vote of G. Marshall. J. Besnard (University of Dundee) contributed to the vote of A. Hopkins. This work was supported by NIH grant 1U54MH084690 (to the University of New Mexico).

PY - 2009/7

Y1 - 2009/7

N2 - Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.

AB - Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.

UR - https://www.scopus.com/pages/publications/67650308267

U2 - 10.1038/nchembio0709-441

DO - 10.1038/nchembio0709-441

M3 - Comment/debate

C2 - 19536101

AN - SCOPUS:67650308267

SN - 1552-4450

VL - 5

SP - 441

EP - 447

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 7

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A crowdsourcing evaluation of the NIH chemical probes

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