A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

PRECEDENT Study Group

doi:10.1038/s41523-025-00824-w

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

PRECEDENT Study Group

Research output: Contribution to journal › Article › peer-review

Abstract

Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.

Original language	English
Article number	116
Journal	npj Breast Cancer
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41523-025-00824-w
State	Published - Dec 2025

Access to Document

10.1038/s41523-025-00824-w

Cite this

@article{8161b1c1439b45068467b0e1f657aada,

title = "A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials",

abstract = "Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.",

author = "\{PRECEDENT Study Group\} and Shelley Potter and Kerry Avery and Rosina Ahmed and \{de Boniface\}, Jana and Sanjoy Chatterjee and David Dodwell and Peter Dubsky and Jingjing Federmann and Sandra Finestone and Michael Gnant and Dominik Hlauschek and Hiroji Iwata and Jiang, \{Michael Y.\} and Orit Kaidar-Person and Lee, \{Han Byoel\} and Mairead MacKenzie and Anne Meyn and Philip Poortmans and Fiorita Poulakaki and Richardson, \{Andrea L.\} and Sepulveda, \{Karla A.\} and Spillane, \{Andrew J.\} and Thompson, \{Alastair M.\} and Gustavo Werutsky and Philipp Wittmann and Wright, \{Jean L.\} and Nicholas Zdenkowski and Katherine Cowan and McIntosh, \{Stuart A.\} and Anagha Zope and Marija Zivkovic and Amanda Zeko and Cobos, \{Gast{\'o}n Zatta\} and Jan {\v Z}ateck{\'y} and Youn, \{Hyun Jo\} and Anneza Yiallourou and Janice Yeh and Sanjay Kumar and Lynda Wyld and Stephanie Wong and Ericka Wiebe and Fredrik Warnberg and Irene Wapnir and Melanie Walker and Tabassum Wadasadawala and Ioannis Voutsadakis and Lubna Vohra and Sergi Vidal-Sicart and Ramachandran Venkitaraman and Umesh Velu and Beatriz V{\'a}zquez-Barreiro and Ad Vandermeulen and \{Van Maaren\}, \{Marissa C.\} and Duijnhoven, \{Frederieke Van\} and Hage, \{Jos Van Der\} and Berkmortel, \{Franchette Van Den\} and Antonis Valachis and Jayant Vaidya and Takayuki Ueno and Tove Tvedskov and Pelagia Tsoutsou and Marinos Tsiatas and Mangesh Thorat and Jacqui Thomson and Wajana Thaweerat and Evrim Tezcanli and Liutti, \{Vitor Teixeira\} and Donatienne Taylor and Tavoletta, \{Maria Saveria\} and Megha Tandon and Michael Swinden and Tommaso Susini and Yisihak Suga and Kirsty Stuart and Heidi Stranzl and Philip Spanheimer and \{De Celis\}, \{Enrique Soto Perez\} and Kylie Snook and Fiona Smith and Bhawana Sirohi and Richard Simcock and Aumilto Silva and Zacharoula Sidiropoulou and Mark Sibbering and Mery Shoshkova and Shetty, \{Preethi S.\} and Shashank Shenoy and Shelly Sharma and Iman Sharawy and Mukesh Shanthilal and Jiraporn Setakornnukul and Margherita Serra and Lorenzo Scardina and Constantinos Savva and S{\'a}nchez-M{\'e}ndez, \{Jose I.\} and Salinas, \{Jorge Emilio\} and Sunita Saha and Helena Sackey and Ryu, \{Jai Min\} and Natacha Ruyssers and Nicola Russell and Rubio, \{Isabel T.\} and Francesca Rovera and Laurent Rosset and Chandeena Roshanlall and Beatriz Rojas and Nicola Rocco and Neill Roberts and Margit Riis and Javier Retamales and Tomas Reinert and Andrew Redfern and Lia Rebaza and Rebecca Read and Evangelia Razis and Ivica Ratosa and Smitha Rao and Duvern Ramiah and Rahim, \{Ishtiaq Ur\} and Venkatraman Radhakrishnan and Putora, \{Paul Martin\} and Marina Puchinskaya and Elena Provenzano and Moura, \{Jose Fernando Prado\} and Daniel Portik and Mauro Porpiglia and Matthew Poppe and Razvan Popescu and Katarzyna Pogoda and Antonio Pi{\~n}ero-Madrona and Segura, \{Cristina P{\'e}rez\} and Tamar Peretz-Yablonski and Alice Pellegrini and David Pasquier and Javier Pascual and Lazaros Papadopoulos and Ferrando, \{Amparo Oltra\} and Bagge, \{Roger Olofsson\} and Ira Oikonomou and Seamus O{\textquoteright}Reilly and Conor O{\textquoteright}Neill and Angeliki Nikopoulou and Dejan Nikolic and Toan Nguyen and Kazutaka Narui and S{\'a}nchez, \{Mar{\'i}a Alejandra Naranjo\} and Karez Namiq and Dawid Murawa and Elisabetta Munzone and Miguel{\'a}{\~n}ez, \{Teresa Mu{\~n}oz\} and Jenna Morgan and Angel Montero and Shagun Misra and Minisini, \{Alessandro Marco\} and Sarkis Meterissian and Tuomo Meretoja and Bruno Meduri and Icro Meattini and Shaurav Maulik and Mau, \{Christine I.\} and Norikazu Masuda and Valeria Masiello and Yazan Masannat and Tamara Martos and Martin-Quesada, \{Ana Isabel\} and Covadonga Marti and Karyne Martel and Gustavo Marta and Julie Margenthaler and Yiola Marcou and Maja Maraldo and Willam Mantilla and James Mansell and Pablo Mando and Makris, \{George Marios\} and John Maduro and Pedro Madeira and Iain Macpherson and Emma Macinnes and Melanie Machiels and Manjola Luzi and Diana L{\"u}ftner and Michelle Ludwig and Valenti, \{Elisenda Llabres\} and Rhea Liang and Jeeyeon Lee and Sara Leal and Siobhan Laws and Ian Kunkler and David Krug and Antigoni Kretsi and Michalis Kontos and Apostolos Konstantis and Assia Konsoulova and Ko, \{Hyun Soo\} and Evelyn Klein and Cliona Kirwan and Emma Kipps and Alba Kihn-Alarc{\'o}n and Khan, \{Mah Muneer\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = dec,

doi = "10.1038/s41523-025-00824-w",

language = "English",

volume = "11",

journal = "npj Breast Cancer",

issn = "2374-4677",

number = "1",

}

TY - JOUR

T1 - A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

AU - PRECEDENT Study Group

AU - Potter, Shelley

AU - Avery, Kerry

AU - Ahmed, Rosina

AU - de Boniface, Jana

AU - Chatterjee, Sanjoy

AU - Dodwell, David

AU - Dubsky, Peter

AU - Federmann, Jingjing

AU - Finestone, Sandra

AU - Gnant, Michael

AU - Hlauschek, Dominik

AU - Iwata, Hiroji

AU - Jiang, Michael Y.

AU - Kaidar-Person, Orit

AU - Lee, Han Byoel

AU - MacKenzie, Mairead

AU - Meyn, Anne

AU - Poortmans, Philip

AU - Poulakaki, Fiorita

AU - Richardson, Andrea L.

AU - Sepulveda, Karla A.

AU - Spillane, Andrew J.

AU - Thompson, Alastair M.

AU - Werutsky, Gustavo

AU - Wittmann, Philipp

AU - Wright, Jean L.

AU - Zdenkowski, Nicholas

AU - Cowan, Katherine

AU - McIntosh, Stuart A.

AU - Zope, Anagha

AU - Zivkovic, Marija

AU - Zeko, Amanda

AU - Cobos, Gastón Zatta

AU - Žatecký, Jan

AU - Youn, Hyun Jo

AU - Yiallourou, Anneza

AU - Yeh, Janice

AU - Kumar, Sanjay

AU - Wyld, Lynda

AU - Wong, Stephanie

AU - Wiebe, Ericka

AU - Warnberg, Fredrik

AU - Wapnir, Irene

AU - Walker, Melanie

AU - Wadasadawala, Tabassum

AU - Voutsadakis, Ioannis

AU - Vohra, Lubna

AU - Vidal-Sicart, Sergi

AU - Venkitaraman, Ramachandran

AU - Velu, Umesh

AU - Vázquez-Barreiro, Beatriz

AU - Vandermeulen, Ad

AU - Van Maaren, Marissa C.

AU - Duijnhoven, Frederieke Van

AU - Hage, Jos Van Der

AU - Berkmortel, Franchette Van Den

AU - Valachis, Antonis

AU - Vaidya, Jayant

AU - Ueno, Takayuki

AU - Tvedskov, Tove

AU - Tsoutsou, Pelagia

AU - Tsiatas, Marinos

AU - Thorat, Mangesh

AU - Thomson, Jacqui

AU - Thaweerat, Wajana

AU - Tezcanli, Evrim

AU - Liutti, Vitor Teixeira

AU - Taylor, Donatienne

AU - Tavoletta, Maria Saveria

AU - Tandon, Megha

AU - Swinden, Michael

AU - Susini, Tommaso

AU - Suga, Yisihak

AU - Stuart, Kirsty

AU - Stranzl, Heidi

AU - Spanheimer, Philip

AU - De Celis, Enrique Soto Perez

AU - Snook, Kylie

AU - Smith, Fiona

AU - Sirohi, Bhawana

AU - Simcock, Richard

AU - Silva, Aumilto

AU - Sidiropoulou, Zacharoula

AU - Sibbering, Mark

AU - Shoshkova, Mery

AU - Shetty, Preethi S.

AU - Shenoy, Shashank

AU - Sharma, Shelly

AU - Sharawy, Iman

AU - Shanthilal, Mukesh

AU - Setakornnukul, Jiraporn

AU - Serra, Margherita

AU - Scardina, Lorenzo

AU - Savva, Constantinos

AU - Sánchez-Méndez, Jose I.

AU - Salinas, Jorge Emilio

AU - Saha, Sunita

AU - Sackey, Helena

AU - Ryu, Jai Min

AU - Ruyssers, Natacha

AU - Russell, Nicola

AU - Rubio, Isabel T.

AU - Rovera, Francesca

AU - Rosset, Laurent

AU - Roshanlall, Chandeena

AU - Rojas, Beatriz

AU - Rocco, Nicola

AU - Roberts, Neill

AU - Riis, Margit

AU - Retamales, Javier

AU - Reinert, Tomas

AU - Redfern, Andrew

AU - Rebaza, Lia

AU - Read, Rebecca

AU - Razis, Evangelia

AU - Ratosa, Ivica

AU - Rao, Smitha

AU - Ramiah, Duvern

AU - Rahim, Ishtiaq Ur

AU - Radhakrishnan, Venkatraman

AU - Putora, Paul Martin

AU - Puchinskaya, Marina

AU - Provenzano, Elena

AU - Moura, Jose Fernando Prado

AU - Portik, Daniel

AU - Porpiglia, Mauro

AU - Poppe, Matthew

AU - Popescu, Razvan

AU - Pogoda, Katarzyna

AU - Piñero-Madrona, Antonio

AU - Segura, Cristina Pérez

AU - Peretz-Yablonski, Tamar

AU - Pellegrini, Alice

AU - Pasquier, David

AU - Pascual, Javier

AU - Papadopoulos, Lazaros

AU - Ferrando, Amparo Oltra

AU - Bagge, Roger Olofsson

AU - Oikonomou, Ira

AU - O’Reilly, Seamus

AU - O’Neill, Conor

AU - Nikopoulou, Angeliki

AU - Nikolic, Dejan

AU - Nguyen, Toan

AU - Narui, Kazutaka

AU - Sánchez, María Alejandra Naranjo

AU - Namiq, Karez

AU - Murawa, Dawid

AU - Munzone, Elisabetta

AU - Migueláñez, Teresa Muñoz

AU - Morgan, Jenna

AU - Montero, Angel

AU - Misra, Shagun

AU - Minisini, Alessandro Marco

AU - Meterissian, Sarkis

AU - Meretoja, Tuomo

AU - Meduri, Bruno

AU - Meattini, Icro

AU - Maulik, Shaurav

AU - Mau, Christine I.

AU - Masuda, Norikazu

AU - Masiello, Valeria

AU - Masannat, Yazan

AU - Martos, Tamara

AU - Martin-Quesada, Ana Isabel

AU - Marti, Covadonga

AU - Martel, Karyne

AU - Marta, Gustavo

AU - Margenthaler, Julie

AU - Marcou, Yiola

AU - Maraldo, Maja

AU - Mantilla, Willam

AU - Mansell, James

AU - Mando, Pablo

AU - Makris, George Marios

AU - Maduro, John

AU - Madeira, Pedro

AU - Macpherson, Iain

AU - Macinnes, Emma

AU - Machiels, Melanie

AU - Luzi, Manjola

AU - Lüftner, Diana

AU - Ludwig, Michelle

AU - Valenti, Elisenda Llabres

AU - Liang, Rhea

AU - Lee, Jeeyeon

AU - Leal, Sara

AU - Laws, Siobhan

AU - Kunkler, Ian

AU - Krug, David

AU - Kretsi, Antigoni

AU - Kontos, Michalis

AU - Konstantis, Apostolos

AU - Konsoulova, Assia

AU - Ko, Hyun Soo

AU - Klein, Evelyn

AU - Kirwan, Cliona

AU - Kipps, Emma

AU - Kihn-Alarcón, Alba

AU - Khan, Mah Muneer

PY - 2025/12

Y1 - 2025/12

N2 - Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.

AB - Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.

UR - https://www.scopus.com/pages/publications/105022312929

U2 - 10.1038/s41523-025-00824-w

DO - 10.1038/s41523-025-00824-w

M3 - Article

C2 - 41152314

AN - SCOPUS:105022312929

SN - 2374-4677

VL - 11

JO - npj Breast Cancer

JF - npj Breast Cancer

IS - 1

M1 - 116

ER -

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

Abstract

Access to Document

Other files and links

Fingerprint

Cite this