A Core Outcome Measurement Set for Pediatric Critical Care

for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN); Mary E. Hartman; John C. Lin

doi:10.1097/PCC.0000000000003055

A Core Outcome Measurement Set for Pediatric Critical Care

for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN), Mary E. Hartman, John C. Lin

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objectives: To identify a PICU Core Outcome Measurement Set (PICU COMS), a set of measures that can be used to evaluate the PICU Core Outcome Set (PICU COS) domains in PICU patients and their families. Design: A modified Delphi consensus process. Setting: Four webinars attended by PICU physicians and nurses, pediatric surgeons, rehabilitation physicians, and scientists with expertise in PICU clinical care or research (n = 35). Attendees were from eight countries and convened from the Pediatric Acute Lung Injury and Sepsis Investigators Pediatric Outcomes STudies after PICU Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network PICU COS Investigators. Subjects: Measures to assess outcome domains of the PICU COS are as follows: cognitive, emotional, overall (including health-related quality of life), physical, and family health. Measures evaluating social health were also considered. Interventions: None. Measurements and Main Results: Measures were classified as general or additional based on generalizability across PICU populations, feasibility, and relevance to specific COS domains. Measures with high consensus, defined as 80% agreement for inclusion, were selected for the PICU COMS. Among 140 candidate measures, 24 were delineated as general (broadly applicable) and, of these, 10 achieved consensus for inclusion in the COMS (7 patient-oriented and 3 family-oriented). Six of the seven patient measures were applicable to the broadest range of patients, diagnoses, and developmental abilities. All were validated in pediatric populations and have normative pediatric data. Twenty additional measures focusing on specific populations or in-depth evaluation of a COS subdomain also met consensus for inclusion as COMS additional measures. Conclusions: The PICU COMS delineates measures to evaluate domains in the PICU COS and facilitates comparability across future research studies to characterize PICU survivorship and enable interventional studies to target long-term outcomes after critical illness.

Original language	English
Pages (from-to)	893-907
Number of pages	15
Journal	Pediatric Critical Care Medicine
Volume	23
Issue number	11
DOIs	https://doi.org/10.1097/PCC.0000000000003055
State	Published - Nov 1 2022

Keywords

critical care outcomes
family health
intensive care units
patient outcome assessment
pediatric
survivorship

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10.1097/PCC.0000000000003055

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for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN), Hartman, M. E., & Lin, J. C. (2022). A Core Outcome Measurement Set for Pediatric Critical Care. Pediatric Critical Care Medicine, 23(11), 893-907. https://doi.org/10.1097/PCC.0000000000003055

for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) ; Hartman, Mary E. ; Lin, John C. / A Core Outcome Measurement Set for Pediatric Critical Care. In: Pediatric Critical Care Medicine. 2022 ; Vol. 23, No. 11. pp. 893-907.

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title = "A Core Outcome Measurement Set for Pediatric Critical Care",

abstract = "Objectives: To identify a PICU Core Outcome Measurement Set (PICU COMS), a set of measures that can be used to evaluate the PICU Core Outcome Set (PICU COS) domains in PICU patients and their families. Design: A modified Delphi consensus process. Setting: Four webinars attended by PICU physicians and nurses, pediatric surgeons, rehabilitation physicians, and scientists with expertise in PICU clinical care or research (n = 35). Attendees were from eight countries and convened from the Pediatric Acute Lung Injury and Sepsis Investigators Pediatric Outcomes STudies after PICU Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network PICU COS Investigators. Subjects: Measures to assess outcome domains of the PICU COS are as follows: cognitive, emotional, overall (including health-related quality of life), physical, and family health. Measures evaluating social health were also considered. Interventions: None. Measurements and Main Results: Measures were classified as general or additional based on generalizability across PICU populations, feasibility, and relevance to specific COS domains. Measures with high consensus, defined as 80% agreement for inclusion, were selected for the PICU COMS. Among 140 candidate measures, 24 were delineated as general (broadly applicable) and, of these, 10 achieved consensus for inclusion in the COMS (7 patient-oriented and 3 family-oriented). Six of the seven patient measures were applicable to the broadest range of patients, diagnoses, and developmental abilities. All were validated in pediatric populations and have normative pediatric data. Twenty additional measures focusing on specific populations or in-depth evaluation of a COS subdomain also met consensus for inclusion as COMS additional measures. Conclusions: The PICU COMS delineates measures to evaluate domains in the PICU COS and facilitates comparability across future research studies to characterize PICU survivorship and enable interventional studies to target long-term outcomes after critical illness.",

keywords = "critical care outcomes, family health, intensive care units, patient outcome assessment, pediatric, survivorship",

author = "{for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)} and Pinto, {Neethi P.} and Maddux, {Aline B.} and Dervan, {Leslie A.} and Woodruff, {Alan G.} and Jarvis, {Jessica M.} and Sholeen Nett and Killien, {Elizabeth Y.} and Graham, {Robert J.} and Karen Choong and Luckett, {Peter M.} and Heneghan, {Julia A.} and Katherine Biagas and Carlton, {Erin F.} and Hartman, {Mary E.} and Lauren Yagiela and Michelson, {Kelly N.} and Manning, {Joseph C.} and Long, {Debbie A.} and Lee, {Jan Hau} and Slomine, {Beth S.} and Beers, {Sue R.} and Trevor Hall and Morrow, {Brenda M.} and Kathleen Meert and {Arias Lopez}, {Maria Del Pilar} and Hennie Knoester and Amy Houtrow and Lenora Olson and Lisa Steele and Schlapbach, {Luregn J.} and Burd, {Randall S.} and Ruth Grosskreuz and Warwick Butt and Fink, {Ericka L.} and Watson, {R. Scott} and Watson, {R. Scott} and Mike Cronin and Andy Geneslaw and Michele Loi and Sarah Murphy and Vinay Nadkarni and Nielsen, {Katie R.} and Shein, {Steven L.} and Kristen Smith and Samer Abu-Sultaneh and Alexis Topjian and Reinis Balmaks and {Di Gennaro}, {Jane (Lin)} and Farris, {Reid W.D.} and Madhura Hallman and Mara Leimanis and Mary McNally and Julie Menzies and {Van Damme}, Danielle and Whitney, {Jane E.} and Hoehn, {K. Sarah} and Neelima Marupudi and Jonna Clark and Jarvis, {J. Dean} and Laura Loftis and Muszynski, {Jennifer A.} and Brian Rissmiller and Marcy Singleton and Ben White and Jerry Zimmerman and Alcamo, {Alicia M.} and Ames, {Stefanie G.} and Anoopindar Bhalla and Meredith Bone and Hunter, {Jay M.} and Kudchadkar, {Sapna R.} and Haifa Mtaweh and Andrew Prout and Madiha Raees and Roberts, {Joan S.} and Shilpa Shah and Manzilat Akande and Kevin Hummel and Catherine Madurski and O'Meara, {Am Iqbal} and Elizabeth Pace and Monique Radman and Mekela Whyte-Nesfield and Christie, {Lee Ann M.} and Sabrina Derrington and Idris Evans and Goodman, {Denise M.} and Simon Li and Lin, {John C.} and Madden, {Maureen A.} and Lindy Moake and Slain, {Katherine N.} and Vandenbranden, {Sara K.} and Berg, {Robert A.} and Carcillo, {Joseph A.} and Dean, {J. Michael} and Hall, {Mark W.} and McQuillen, {Patrick S.} and Mourani, {Peter M.} and Pollack, {Murray M.} and Anil Sapru and David Wessel and Athena Zuppa",

year = "2022",

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language = "English",

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for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN), Hartman, ME & Lin, JC 2022, 'A Core Outcome Measurement Set for Pediatric Critical Care', Pediatric Critical Care Medicine, vol. 23, no. 11, pp. 893-907. https://doi.org/10.1097/PCC.0000000000003055

A Core Outcome Measurement Set for Pediatric Critical Care. / for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN) ; Hartman, Mary E.; Lin, John C.
In: Pediatric Critical Care Medicine, Vol. 23, No. 11, 01.11.2022, p. 893-907.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Core Outcome Measurement Set for Pediatric Critical Care

AU - for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CP

AU - Pinto, Neethi P.

AU - Maddux, Aline B.

AU - Dervan, Leslie A.

AU - Woodruff, Alan G.

AU - Jarvis, Jessica M.

AU - Nett, Sholeen

AU - Killien, Elizabeth Y.

AU - Graham, Robert J.

AU - Choong, Karen

AU - Luckett, Peter M.

AU - Heneghan, Julia A.

AU - Biagas, Katherine

AU - Carlton, Erin F.

AU - Hartman, Mary E.

AU - Yagiela, Lauren

AU - Michelson, Kelly N.

AU - Manning, Joseph C.

AU - Long, Debbie A.

AU - Lee, Jan Hau

AU - Slomine, Beth S.

AU - Beers, Sue R.

AU - Hall, Trevor

AU - Morrow, Brenda M.

AU - Meert, Kathleen

AU - Arias Lopez, Maria Del Pilar

AU - Knoester, Hennie

AU - Houtrow, Amy

AU - Olson, Lenora

AU - Steele, Lisa

AU - Schlapbach, Luregn J.

AU - Burd, Randall S.

AU - Grosskreuz, Ruth

AU - Butt, Warwick

AU - Fink, Ericka L.

AU - Watson, R. Scott

AU - Cronin, Mike

AU - Geneslaw, Andy

AU - Loi, Michele

AU - Murphy, Sarah

AU - Nadkarni, Vinay

AU - Nielsen, Katie R.

AU - Shein, Steven L.

AU - Smith, Kristen

AU - Abu-Sultaneh, Samer

AU - Topjian, Alexis

AU - Balmaks, Reinis

AU - Di Gennaro, Jane (Lin)

AU - Farris, Reid W.D.

AU - Hallman, Madhura

AU - Leimanis, Mara

AU - McNally, Mary

AU - Menzies, Julie

AU - Van Damme, Danielle

AU - Whitney, Jane E.

AU - Hoehn, K. Sarah

AU - Marupudi, Neelima

AU - Clark, Jonna

AU - Jarvis, J. Dean

AU - Loftis, Laura

AU - Muszynski, Jennifer A.

AU - Rissmiller, Brian

AU - Singleton, Marcy

AU - White, Ben

AU - Zimmerman, Jerry

AU - Alcamo, Alicia M.

AU - Ames, Stefanie G.

AU - Bhalla, Anoopindar

AU - Bone, Meredith

AU - Hunter, Jay M.

AU - Kudchadkar, Sapna R.

AU - Mtaweh, Haifa

AU - Prout, Andrew

AU - Raees, Madiha

AU - Roberts, Joan S.

AU - Shah, Shilpa

AU - Akande, Manzilat

AU - Hummel, Kevin

AU - Madurski, Catherine

AU - O'Meara, Am Iqbal

AU - Pace, Elizabeth

AU - Radman, Monique

AU - Whyte-Nesfield, Mekela

AU - Christie, Lee Ann M.

AU - Derrington, Sabrina

AU - Evans, Idris

AU - Goodman, Denise M.

AU - Li, Simon

AU - Lin, John C.

AU - Madden, Maureen A.

AU - Moake, Lindy

AU - Slain, Katherine N.

AU - Vandenbranden, Sara K.

AU - Berg, Robert A.

AU - Carcillo, Joseph A.

AU - Dean, J. Michael

AU - Hall, Mark W.

AU - McQuillen, Patrick S.

AU - Mourani, Peter M.

AU - Pollack, Murray M.

AU - Sapru, Anil

AU - Wessel, David

AU - Zuppa, Athena

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Objectives: To identify a PICU Core Outcome Measurement Set (PICU COMS), a set of measures that can be used to evaluate the PICU Core Outcome Set (PICU COS) domains in PICU patients and their families. Design: A modified Delphi consensus process. Setting: Four webinars attended by PICU physicians and nurses, pediatric surgeons, rehabilitation physicians, and scientists with expertise in PICU clinical care or research (n = 35). Attendees were from eight countries and convened from the Pediatric Acute Lung Injury and Sepsis Investigators Pediatric Outcomes STudies after PICU Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network PICU COS Investigators. Subjects: Measures to assess outcome domains of the PICU COS are as follows: cognitive, emotional, overall (including health-related quality of life), physical, and family health. Measures evaluating social health were also considered. Interventions: None. Measurements and Main Results: Measures were classified as general or additional based on generalizability across PICU populations, feasibility, and relevance to specific COS domains. Measures with high consensus, defined as 80% agreement for inclusion, were selected for the PICU COMS. Among 140 candidate measures, 24 were delineated as general (broadly applicable) and, of these, 10 achieved consensus for inclusion in the COMS (7 patient-oriented and 3 family-oriented). Six of the seven patient measures were applicable to the broadest range of patients, diagnoses, and developmental abilities. All were validated in pediatric populations and have normative pediatric data. Twenty additional measures focusing on specific populations or in-depth evaluation of a COS subdomain also met consensus for inclusion as COMS additional measures. Conclusions: The PICU COMS delineates measures to evaluate domains in the PICU COS and facilitates comparability across future research studies to characterize PICU survivorship and enable interventional studies to target long-term outcomes after critical illness.

AB - Objectives: To identify a PICU Core Outcome Measurement Set (PICU COMS), a set of measures that can be used to evaluate the PICU Core Outcome Set (PICU COS) domains in PICU patients and their families. Design: A modified Delphi consensus process. Setting: Four webinars attended by PICU physicians and nurses, pediatric surgeons, rehabilitation physicians, and scientists with expertise in PICU clinical care or research (n = 35). Attendees were from eight countries and convened from the Pediatric Acute Lung Injury and Sepsis Investigators Pediatric Outcomes STudies after PICU Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network PICU COS Investigators. Subjects: Measures to assess outcome domains of the PICU COS are as follows: cognitive, emotional, overall (including health-related quality of life), physical, and family health. Measures evaluating social health were also considered. Interventions: None. Measurements and Main Results: Measures were classified as general or additional based on generalizability across PICU populations, feasibility, and relevance to specific COS domains. Measures with high consensus, defined as 80% agreement for inclusion, were selected for the PICU COMS. Among 140 candidate measures, 24 were delineated as general (broadly applicable) and, of these, 10 achieved consensus for inclusion in the COMS (7 patient-oriented and 3 family-oriented). Six of the seven patient measures were applicable to the broadest range of patients, diagnoses, and developmental abilities. All were validated in pediatric populations and have normative pediatric data. Twenty additional measures focusing on specific populations or in-depth evaluation of a COS subdomain also met consensus for inclusion as COMS additional measures. Conclusions: The PICU COMS delineates measures to evaluate domains in the PICU COS and facilitates comparability across future research studies to characterize PICU survivorship and enable interventional studies to target long-term outcomes after critical illness.

KW - critical care outcomes

KW - family health

KW - intensive care units

KW - patient outcome assessment

KW - pediatric

KW - survivorship

UR - http://www.scopus.com/inward/record.url?scp=85139985014&partnerID=8YFLogxK

U2 - 10.1097/PCC.0000000000003055

DO - 10.1097/PCC.0000000000003055

M3 - Article

C2 - 36040097

AN - SCOPUS:85139985014

SN - 1529-7535

VL - 23

SP - 893

EP - 907

JO - Pediatric Critical Care Medicine

JF - Pediatric Critical Care Medicine

IS - 11

ER -

for the POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN), Hartman ME , Lin JC. A Core Outcome Measurement Set for Pediatric Critical Care. Pediatric Critical Care Medicine. 2022 Nov 1;23(11):893-907. doi: 10.1097/PCC.0000000000003055

A Core Outcome Measurement Set for Pediatric Critical Care

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