TY - JOUR
T1 - A Comprehensive Review of HER2 in Cancer Biology and Therapeutics
AU - Cheng, Xiaoqing
N1 - Publisher Copyright:
© 2024 by the author.
PY - 2024/7
Y1 - 2024/7
N2 - Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial role in cell proliferation, survival, and differentiation. Aberrant HER2 signaling is implicated in various cancers, particularly in breast and gastric cancers, where HER2 overexpression or amplification correlates with aggressive tumor behavior and poor prognosis. HER2-activating mutations contribute to accelerated tumorigenesis and metastasis. This review provides an overview of HER2 biology, signaling pathways, mechanisms of dysregulation, and diagnostic approaches, as well as therapeutic strategies targeting HER2 in cancer. Understanding the intricate details of HER2 regulation is essential for developing effective targeted therapies and improving patient outcomes.
AB - Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial role in cell proliferation, survival, and differentiation. Aberrant HER2 signaling is implicated in various cancers, particularly in breast and gastric cancers, where HER2 overexpression or amplification correlates with aggressive tumor behavior and poor prognosis. HER2-activating mutations contribute to accelerated tumorigenesis and metastasis. This review provides an overview of HER2 biology, signaling pathways, mechanisms of dysregulation, and diagnostic approaches, as well as therapeutic strategies targeting HER2 in cancer. Understanding the intricate details of HER2 regulation is essential for developing effective targeted therapies and improving patient outcomes.
KW - ADC
KW - cancer
KW - HER2
KW - immune regulation
KW - metastasis
KW - therapeutics
UR - http://www.scopus.com/inward/record.url?scp=85199892801&partnerID=8YFLogxK
U2 - 10.3390/genes15070903
DO - 10.3390/genes15070903
M3 - Review article
C2 - 39062682
AN - SCOPUS:85199892801
SN - 2073-4425
VL - 15
JO - Genes
JF - Genes
IS - 7
M1 - 903
ER -