In this article, Karch, Temple and colleagues describe a resource of fibroblasts, patient-derived induced pluripotent stem cells, and genome engineered stem cells with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for primary tauopathies.

Original languageEnglish
Pages (from-to)939-955
Number of pages17
JournalStem Cell Reports
Issue number5
StatePublished - Nov 12 2019


  • CRISPR/Cas9
  • MAPT
  • corticobasal degeneration
  • fibroblasts
  • frontotemporal dementia
  • induced pluripotent stem cells
  • neural progenitor cells
  • progressive supranuclear palsy
  • tau
  • tauopathy


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