TY - JOUR
T1 - A comprehensive analysis of the androgen receptor gene and risk of breast cancer
T2 - Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
AU - Cox, David G.
AU - Blanché, Hélène
AU - Pearce, Celeste L.
AU - Calle, Eugenia E.
AU - Colditz, Graham R.
AU - Pike, Malcolm C.
AU - Albanes, Demetrius
AU - Allen, Naomi E.
AU - Amiano, Pilar
AU - Berglund, Goran
AU - Boeing, Heiner
AU - Buring, Julie
AU - Burtt, Noel
AU - Canzian, Federico
AU - Chanock, Stephen
AU - Clavel-Chapelon, Françoise
AU - Feigelson, Heather Spencer
AU - Freedman, Matthew
AU - Haiman, Christopher A.
AU - Hankinson, Susan E.
AU - Henderson, Brian E.
AU - Hoover, Robert
AU - Hunter, David J.
AU - Kaaks, Rudolf
AU - Kolonel, Laurence
AU - Kraft, Peter
AU - LeMarchand, Loic
AU - Lund, Eiliv
AU - Palli, Domenico
AU - Peeters, Petra H.M.
AU - Riboli, Elio
AU - Stram, Daniel O.
AU - Thun, Michael
AU - Tjonneland, Anne
AU - Trichopoulos, Dimitrios
AU - Yeager, Meredith
PY - 2006/9/20
Y1 - 2006/9/20
N2 - Introduction: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/ or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Methods: The underlying genetic variation was determined by first sequencing the coding regions of the AR gene in a panel of 95 advanced breast cancer cases. Second, a dense set of markers from the public database was genotyped in a panel of 349 healthy women. The linkage disequilibrium relationships (blocks) across the gene were then identified, and haplotypetagging single nucleotide polymorphisms (htSNPs) were selected to capture the common genetic variation across the locus. The htSNPs were then genotyped in the nested breast cancer cases and controls from the Cancer Prevention Study II, European Prospective Investigation into Cancer and Nutrition, Multiethnic Cohort, Nurses' Health Study, and Women's Health Study cohorts (5,603 breast cancer cases and 7,480 controls). Results: We found no association between any genetic variation (SNP, haplotype, or the exon 1 CAG repeat) in the AR gene and risk of breast cancer, nor were any statistical interactions with known breast cancer risk factors observed. Conclusion: Among postmenopausal Caucasian women, common variants of the AR gene are not associated with risk of breast cancer.
AB - Introduction: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/ or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Methods: The underlying genetic variation was determined by first sequencing the coding regions of the AR gene in a panel of 95 advanced breast cancer cases. Second, a dense set of markers from the public database was genotyped in a panel of 349 healthy women. The linkage disequilibrium relationships (blocks) across the gene were then identified, and haplotypetagging single nucleotide polymorphisms (htSNPs) were selected to capture the common genetic variation across the locus. The htSNPs were then genotyped in the nested breast cancer cases and controls from the Cancer Prevention Study II, European Prospective Investigation into Cancer and Nutrition, Multiethnic Cohort, Nurses' Health Study, and Women's Health Study cohorts (5,603 breast cancer cases and 7,480 controls). Results: We found no association between any genetic variation (SNP, haplotype, or the exon 1 CAG repeat) in the AR gene and risk of breast cancer, nor were any statistical interactions with known breast cancer risk factors observed. Conclusion: Among postmenopausal Caucasian women, common variants of the AR gene are not associated with risk of breast cancer.
UR - http://www.scopus.com/inward/record.url?scp=33750542952&partnerID=8YFLogxK
U2 - 10.1186/bcr1602
DO - 10.1186/bcr1602
M3 - Article
C2 - 16987421
AN - SCOPUS:33750542952
SN - 1465-5411
VL - 8
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 5
M1 - R54
ER -