A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children

J. K. Makkar, N. Bhatia, I. Bala, D. Dwivedi, P. M. Singh

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Emergence delirium is a common problem in children recovering from general anaesthesia. We performed a study comparing emergence characteristics in 100 patients who were randomly allocated to receive either 0.3 μg.kg-1 dexmedetomidine, 1 mg.kg-1 propofol or saline 0.9% and undergoing infra-umbilical surgery. The Pediatric Anesthesia Emergence Delirium scale was used to grade emergence delirium. Emergence delirium occurred in 9.4% of children in the dexmedetomidine group compared with 13.9% in the propofol group and 40.6% in the control group (p = 0.004). In the dexmedetomidine group, sedation occurred in 62.5% of children at 10 min after transfer to the recovery area, compared with 44.4% in the propofol group and 12.5% in the control group (p = 0.010). We conclude that dexmedetomidine significantly reduced the incidence of emergence delirium but this was at the expense of a greater incidence of sedation in the recovery period.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalAnaesthesia
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2016

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