A Comparative Biochemical and Pathological Evaluation of Brain Samples from Knock-In Murine Models of Gaucher Disease

Keyphrases

• Knock-in Mouse Model 100%
• Murine Model 100%
• Pathological Examination 100%
• Gaucher Disease 100%
• Biochemical Assessment 100%
• Brain Samples 100%
• D409H 100%
• L444P 80%
• Mutant Mice 60%
• Glucosylsphingosine 60%
• Glucocerebrosidase Activity 40%
• Glucocerebrosidase 40%
• Wild Mice 20%
• Neuroinflammation 20%
• Genotype 20%
• Alpha-synuclein (α-syn) 20%
• Lysosomal Storage Disease 20%
• Enzymatic Activity 20%
• Genetic Background 20%
• Dopaminergic Neuron Loss 20%
• Biochemical Analysis 20%
• Gaucher 20%
• Lipid Accumulation 20%
• Motor Behavior 20%
• Null Allele 20%
• Pathological Phenotype 20%
• Pathologic Analysis 20%
• Biallelic mutations 20%
• GBA1 20%
• Aged Animals 20%
• Glucocerebroside 20%

Biochemistry, Genetics and Molecular Biology

• Gaucher's Disease 100%
• Glucosylceramidase 80%
• Glucocerebrosidase 80%
• Mouse Mutant 60%
• Wild Type Mouse 20%
• Enzyme Activity 20%
• Lipid Storage 20%
• Dopaminergic 20%
• Genetic Background 20%
• Murine 20%
• Alpha-Synuclein 20%
• Null Allele 20%
• Locomotion 20%
• Glucocerebroside 20%

Neuroscience

• Glucosylceramidase 100%
• Dopaminergic 25%
• Behavior (Neuroscience) 25%
• Enzyme Activity 25%
• Alpha-Synuclein 25%
• Null Allele 25%
• Glucosylceramide 25%