A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells

Marco Colonna, Francisco Navarro, Teresa Bellón, Manuel Llano, Pilar García, Jacqueline Samaridis, Lena Angman, Marina Cella, Miguel López-Botet

Research output: Contribution to journalArticlepeer-review

769 Scopus citations

Abstract

Natural killer (NK) cell-mediated lysis is negatively regulated by killer cell inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules. In this study, we characterize a novel inhibitory MHC class I receptor of the immunoglobulin-superfamily, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells. This receptor, called Ig-like transcript (ILT)2, binds MHC class I molecules and delivers a negative signal that inhibits killing by NK and T cells, as well as Ca2+ mobilization in B cells and myelomonocytic cells triggered through the B cell antigen receptor and human histocompatibility leukocyte antigens (HLA)-DR, respectively. In addition, myelomonocytic cells express receptors homologous to ILT2, which are characterized by extensive polymorphism and might recognize distinct HLA class I molecules. These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response.

Original languageEnglish
Pages (from-to)1809-1818
Number of pages10
JournalJournal of Experimental Medicine
Volume186
Issue number11
DOIs
StatePublished - Dec 1 1997

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