A commingling analysis of platelet monoamine oxidase activity

John Rice; Peter McGuffin; Edward G. Shaskan

doi:10.1016/0165-1781(82)90069-5

A commingling analysis of platelet monoamine oxidase activity

John Rice, Peter McGuffin, Edward G. Shaskan

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Abstract

The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity being controlled by a single major locus with a gene frequency of 0.02 for high-MAO activity. Accordingly, it is unlikely that such a locus could serve as a genetic marker for a disorder which is associated with low activity. However, this finding does not rule out the possibility that MAO activity is an associated risk factor in disease.

Original language	English
Pages (from-to)	325-335
Number of pages	11
Journal	Psychiatry Research
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(82)90069-5
State	Published - Dec 1982

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title = "A commingling analysis of platelet monoamine oxidase activity",

abstract = "The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity being controlled by a single major locus with a gene frequency of 0.02 for high-MAO activity. Accordingly, it is unlikely that such a locus could serve as a genetic marker for a disorder which is associated with low activity. However, this finding does not rule out the possibility that MAO activity is an associated risk factor in disease.",

author = "John Rice and Peter McGuffin and Shaskan, {Edward G.}",

note = "Funding Information: The research reported was supported in part by USPHS grants AA-03539, MH-25430, MH-31302, AI-15901, and an MRC Fellowship (U.K.) for Dr. McGuffin.",

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AU - McGuffin, Peter

AU - Shaskan, Edward G.

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PY - 1982/12

Y1 - 1982/12

N2 - The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity being controlled by a single major locus with a gene frequency of 0.02 for high-MAO activity. Accordingly, it is unlikely that such a locus could serve as a genetic marker for a disorder which is associated with low activity. However, this finding does not rule out the possibility that MAO activity is an associated risk factor in disease.

AB - The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity being controlled by a single major locus with a gene frequency of 0.02 for high-MAO activity. Accordingly, it is unlikely that such a locus could serve as a genetic marker for a disorder which is associated with low activity. However, this finding does not rule out the possibility that MAO activity is an associated risk factor in disease.

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A commingling analysis of platelet monoamine oxidase activity

Abstract

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