A combined modality therapeutic approach to metastatic anal squamous cell carcinoma with systemic chemotherapy and local therapy to sites of disease: Case report and review of literature

Rosana Gnanajothy, Graham W. Warren, Sherry Okun, Lindsay L. Peterson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Cases of metastatic anal carcinoma managed with a combination of systemic chemotherapy and local therapies to both solitary sites of metastases and the primary site have been reported in the literature. We present a case of a 55-year-old male with metastatic anal squamous cell carcinoma to the liver treated with induction chemotherapy with cisplatin (CDDP) and 5-fluorouracil (5FU) followed by liver resection and radiation to the anal primary with concurrent 5FU and mitomycin. This approach resulted in control of disease without evidence of recurrence, and no increased toxicities now 19 months from initial diagnosis to time of reporting. This novel approach resulted in a good treatment response as documented by imaging and symptom improvement and a long disease free interval.

Original languageEnglish
Pages (from-to)E58-E63
JournalJournal of Gastrointestinal Oncology
Volume7
Issue number3
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • Anal carcinoma
  • Chemoradiation
  • Induction chemotherapy
  • Liver metastasectomy

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