TY - JOUR
T1 - A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3
AU - Radosavljevic, Mirjana
AU - Cuillerier, Benot
AU - Wilson, Michael J.
AU - Clément, Oliver
AU - Wicker, Sophie
AU - Gilfillan, Susan
AU - Beck, Stephan
AU - Trowsdale, John
AU - Bahram, Seiamak
N1 - Funding Information:
We thank the entire chromosome 6 project group at the Sanger Centre (http://www.sanger.ac.uk/HGP/Chr6/team.shtml), in particular Sarah Blakey, Roger Horton, Sarah Milne, Andrew Mungall, Sarah Sims, and Alan Tracey. This work was supported by the INSERM-Contrat de Recherche Stratégique (CReS), the Actions Concertées Incitatives Jeunes Chercheurs and Biologie du Développement et Physiologie Intégrative-Ministère de la Recherche, the Action Recherche Santé 2000-Fondation pour la Recherche Médicale, the Association pour la Recherche sur le Cancer, and the Ligues Départementales et Nationales contre le Cancer. Human sequencing at the Sanger Centre and J.T.Õs laboratory is funded by the Wellcome Trust.
PY - 2002/1
Y1 - 2002/1
N2 - We have identified a novel family of human major histocompatibility complex (MHC) class I genes. This MHC class I related gene family is defined by 10 members, among which 6 encode potentially functional glycoproteins. The 180-kb cluster containing them has been generated by serial duplication and minimal diversification of an ancestral prototype. They are not located within the MHC on 6p21.3, but near the tip of its long arm at q24.2-q25.3, close to the human equivalent of the mouse H2-linked t-complex, a subchromosomal region syntenic to a segment of mouse chromosome 10 harboring the orthologous MHC class I related retinoic acid early transcript loci, Raet1a-d. Hence we have named the identified loci RAET1E-N. Human RAET1 products are all devoid of the membrane-proximal immunoglobulin-like α3 domain and most, but not all, are predicted to remain membrane-anchored via glycosylphosphatidylinositol linkage and are shown to display an atypical pattern of polymorphism. RAET1 transcripts are absent from hematopoietic tissues, but largely expressed in tumors. The involvement of orthologous mouse RAET1A-D/H60 in natural killer and T cell activation through NKG2D engagement augurs a similar function for the human RAET1 proteins.
AB - We have identified a novel family of human major histocompatibility complex (MHC) class I genes. This MHC class I related gene family is defined by 10 members, among which 6 encode potentially functional glycoproteins. The 180-kb cluster containing them has been generated by serial duplication and minimal diversification of an ancestral prototype. They are not located within the MHC on 6p21.3, but near the tip of its long arm at q24.2-q25.3, close to the human equivalent of the mouse H2-linked t-complex, a subchromosomal region syntenic to a segment of mouse chromosome 10 harboring the orthologous MHC class I related retinoic acid early transcript loci, Raet1a-d. Hence we have named the identified loci RAET1E-N. Human RAET1 products are all devoid of the membrane-proximal immunoglobulin-like α3 domain and most, but not all, are predicted to remain membrane-anchored via glycosylphosphatidylinositol linkage and are shown to display an atypical pattern of polymorphism. RAET1 transcripts are absent from hematopoietic tissues, but largely expressed in tumors. The involvement of orthologous mouse RAET1A-D/H60 in natural killer and T cell activation through NKG2D engagement augurs a similar function for the human RAET1 proteins.
KW - Chromosome 6q
KW - MHC
KW - MIC
KW - Major histocompatibility complex
KW - RAET1
KW - t-complex
UR - http://www.scopus.com/inward/record.url?scp=0035701536&partnerID=8YFLogxK
U2 - 10.1006/geno.2001.6673
DO - 10.1006/geno.2001.6673
M3 - Article
C2 - 11827464
AN - SCOPUS:0035701536
SN - 0888-7543
VL - 79
SP - 114
EP - 123
JO - Genomics
JF - Genomics
IS - 1
ER -