TY - JOUR
T1 - A clinical picture of Guillain-Barré Syndrome in children in the United States
AU - Hicks, Caitlin W.
AU - Kay, Benjamin
AU - Worley, Sarah E.
AU - Moodley, Manikum
PY - 2010/12
Y1 - 2010/12
N2 - The authors describe the demographics, clinical presentation, investigation, treatment, and outcomes of pediatric patients with Guillain-Barré syndrome. They identified 35 pediatric patients with Guillain-Barré syndrome presenting to a tertiary academic center over a 20-year period. The most common presenting symptoms were paresthesias (54%), weakness (49%), and myalgias (49%). Sensation was affected in 54% of patients, and hyporeflexia or areflexia was present in 94% of patients. Cranial nerve dysfunction (46%) and autonomic involvement (eg, changes in blood pressure, pulse, bowel/bladder control, or priapism; 46%) were also common. Autonomic dysfunction, cranial nerve involvement, and albuminocytological dissociation were significantly associated with a decreased time to nadir, the point when symptoms peaked (P =.015,.007, and.005, respectively). Although not statistically significant, treatment with plasmapheresis had a better success rate than intravenous immunoglobulin. The authors' results will help to further delineate the clinical picture of Guillain-Barré syndrome in children and refine treatment strategies.
AB - The authors describe the demographics, clinical presentation, investigation, treatment, and outcomes of pediatric patients with Guillain-Barré syndrome. They identified 35 pediatric patients with Guillain-Barré syndrome presenting to a tertiary academic center over a 20-year period. The most common presenting symptoms were paresthesias (54%), weakness (49%), and myalgias (49%). Sensation was affected in 54% of patients, and hyporeflexia or areflexia was present in 94% of patients. Cranial nerve dysfunction (46%) and autonomic involvement (eg, changes in blood pressure, pulse, bowel/bladder control, or priapism; 46%) were also common. Autonomic dysfunction, cranial nerve involvement, and albuminocytological dissociation were significantly associated with a decreased time to nadir, the point when symptoms peaked (P =.015,.007, and.005, respectively). Although not statistically significant, treatment with plasmapheresis had a better success rate than intravenous immunoglobulin. The authors' results will help to further delineate the clinical picture of Guillain-Barré syndrome in children and refine treatment strategies.
KW - demyelinating disease
KW - Guillain-Barré syndrome
KW - pediatrics
UR - http://www.scopus.com/inward/record.url?scp=78650196531&partnerID=8YFLogxK
U2 - 10.1177/0883073810370481
DO - 10.1177/0883073810370481
M3 - Article
C2 - 20823034
AN - SCOPUS:78650196531
VL - 25
SP - 1504
EP - 1510
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 12
ER -