TY - JOUR
T1 - A Chromosome‐based method to infer IBD scores for missing and ambiguous markers
AU - Gu, Chi
AU - Suarez, Brian K.
AU - Reich, Theodore
AU - Todorov, Alexandre A.
PY - 1995
Y1 - 1995
N2 - We propose a probability model to impute missing identical‐by‐descent (IBD) vectors for linkage analysis, when adjacent marker loci are typed and interference is estimable. A chromosome‐based IBD distribution, conditioned on available marker data, is computed using a fast algorithm to estimate the joint probability of genes IBD at several equally spaced linked loci. Weighted IBD vectors are then used in various test statistics for linkage analysis. As an example, we analyzed the 18 affected sib pairs in the GAW9 Problem 1 data set using Risch's lod‐score test. © 1995 Wiley‐Liss, Inc.
AB - We propose a probability model to impute missing identical‐by‐descent (IBD) vectors for linkage analysis, when adjacent marker loci are typed and interference is estimable. A chromosome‐based IBD distribution, conditioned on available marker data, is computed using a fast algorithm to estimate the joint probability of genes IBD at several equally spaced linked loci. Weighted IBD vectors are then used in various test statistics for linkage analysis. As an example, we analyzed the 18 affected sib pairs in the GAW9 Problem 1 data set using Risch's lod‐score test. © 1995 Wiley‐Liss, Inc.
KW - IBD distribution
KW - linkage analysis
KW - mapping function
KW - sib‐pair method
UR - http://www.scopus.com/inward/record.url?scp=0029565579&partnerID=8YFLogxK
U2 - 10.1002/gepi.1370120657
DO - 10.1002/gepi.1370120657
M3 - Article
C2 - 8788024
AN - SCOPUS:0029565579
SN - 0741-0395
VL - 12
SP - 871
EP - 876
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - 6
ER -