TY - JOUR
T1 - A case study of voltage-gated potassium channel antibody-related limbic encephalitis with PET/MRI findings
AU - Day, Brian K.
AU - Eisenman, Lawrence
AU - Black, Joseph
AU - Maccotta, Luigi
AU - Hogan, R. Edward
N1 - Publisher Copyright:
© 2015.
PY - 2015/2/4
Y1 - 2015/2/4
N2 - Preclinical and clinical studies have demonstrated the significance of inflammation and autoantibodies in epilepsy, and the use of immunotherapies in certain situations has become an established practice. Temporal lobe epilepsy can follow paraneoplastic or nonparaneoplastic limbic encephalitis associated with antibodies directed against brain antigens. Here, we focus on a patient with worsening confusion and temporal lobe seizures despite treatment with antiepileptic medications. Serial brain MRIs did not conclusively reveal structural abnormalities, so the patient underwent brain PET/MRI to simultaneously evaluate brain structure and function, revealing bitemporal abnormalities. The patient was diagnosed with voltage-gated potassium channel antibody-related limbic encephalitis based on clinical presentation, imaging findings, and antibody testing. Treatment included the addition of a second antiepileptic agent and oral steroids. His seizures and cognitive deficits improved and stabilized.
AB - Preclinical and clinical studies have demonstrated the significance of inflammation and autoantibodies in epilepsy, and the use of immunotherapies in certain situations has become an established practice. Temporal lobe epilepsy can follow paraneoplastic or nonparaneoplastic limbic encephalitis associated with antibodies directed against brain antigens. Here, we focus on a patient with worsening confusion and temporal lobe seizures despite treatment with antiepileptic medications. Serial brain MRIs did not conclusively reveal structural abnormalities, so the patient underwent brain PET/MRI to simultaneously evaluate brain structure and function, revealing bitemporal abnormalities. The patient was diagnosed with voltage-gated potassium channel antibody-related limbic encephalitis based on clinical presentation, imaging findings, and antibody testing. Treatment included the addition of a second antiepileptic agent and oral steroids. His seizures and cognitive deficits improved and stabilized.
KW - Autoimmune epilepsy
KW - Limbic encephalitis
KW - Magnetic resonance imaging
KW - PET/MRI
KW - Positron emission tomography
KW - Voltage-gated potassium channel
UR - http://www.scopus.com/inward/record.url?scp=84931266638&partnerID=8YFLogxK
U2 - 10.1016/j.ebcr.2015.02.002
DO - 10.1016/j.ebcr.2015.02.002
M3 - Article
C2 - 26106579
AN - SCOPUS:84931266638
SN - 2213-3232
VL - 4
SP - 23
EP - 26
JO - Epilepsy and Behavior Case Reports
JF - Epilepsy and Behavior Case Reports
ER -