A case of celiac disease, epilepsy, and cerebral calcifications with temporal lobe epilepsy

This is a case report of a 55-year-old man with medication refractory right temporal lobe epilepsy since adolescence. He was found to have bilateral posterior cerebral calcifications on routine head computed tomography with confirmation on magnetic resonance imaging. He also had elevated antibody markers for celiac disease. He was diagnosed with the rare, but well-described syndrome of celiac disease, epilepsy, and cerebral calcifications (CEC). He failed a brief trial of gluten-free diet and went on to have a right temporal lobectomy with sustained freedom from disabling seizures. This case is an example of the growing recognition of neurologic disorders associated with celiac disease. It also provides an example of the characteristic radiographic sign associated with CEC.