A canine model of paired graft thrombosis

Marshall Hicks, Dan McGraw, Brian Rubin, Dirk Baumann, John Munn, Brent Allen, Charles Anderson, Gregorio Sicard

Research output: Contribution to journalArticle

Abstract

A novel canine model for reliably producing graft thrombosis is described. Two unilateral aortoiliac bypasses are performed while preserving the integrity of the native vascular tree. These grafts are briefly mechanically occluded at the time of the initial operation, and they remain occluded postoperatively because flow is preferentially directed through the largercaliber, thrombo-resistant native circulation. Percutaneous temporary intra-arterial balloon occlusion of the native vessels redirects flow into the occluded graft segments, which can be used in experimental protocols. This new model for studying graft thrombosis requires only a single, simple operative procedure, and easily allows secondary percutaneous graft manipulation.

Original languageEnglish
Pages (from-to)254-257
Number of pages4
JournalInvestigative Radiology
Volume26
Issue number3
DOIs
StatePublished - Mar 1991

Keywords

  • Graft
  • Thrombosis

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    Hicks, M., McGraw, D., Rubin, B., Baumann, D., Munn, J., Allen, B., Anderson, C., & Sicard, G. (1991). A canine model of paired graft thrombosis. Investigative Radiology, 26(3), 254-257. https://doi.org/10.1097/00004424-199103000-00011