TY - JOUR
T1 - A brain-specific G protein gamma subunit
AU - Kalyanaraman, S.
AU - Kalyanaraman, V.
AU - Gautam, N.
PY - 1995/11/2
Y1 - 1995/11/2
N2 - Two different cDNAs for G protein γ subunits have been isolated from mouse brain. One encodes a novel γ subunit, γ4, the expression of which is detected only in brain. A fragment of this cDNA had been isolated previously. The other cDNA encodes γ3, a subunit type previously isolated from bovine brain. The primary structure of the γ3 subunit is conserved completely across species indicating that the diversity in the structure of the γ subunits is of functional consequence. Moreover, γ2, γ3 and γ4, which are predominantly expressed in brain, are more homologous to each other than other γ subunits, indicating that the G protein γ subunits belong to distinct subfamilies similar to the α subunits.
AB - Two different cDNAs for G protein γ subunits have been isolated from mouse brain. One encodes a novel γ subunit, γ4, the expression of which is detected only in brain. A fragment of this cDNA had been isolated previously. The other cDNA encodes γ3, a subunit type previously isolated from bovine brain. The primary structure of the γ3 subunit is conserved completely across species indicating that the diversity in the structure of the γ subunits is of functional consequence. Moreover, γ2, γ3 and γ4, which are predominantly expressed in brain, are more homologous to each other than other γ subunits, indicating that the G protein γ subunits belong to distinct subfamilies similar to the α subunits.
UR - http://www.scopus.com/inward/record.url?scp=0028820584&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1995.2600
DO - 10.1006/bbrc.1995.2600
M3 - Article
C2 - 7488078
AN - SCOPUS:0028820584
SN - 0006-291X
VL - 216
SP - 126
EP - 132
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -