@article{01a3260981f143b89799c1108362f657,
title = "A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease",
abstract = "Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic {\textquoteleft}fat-free{\textquoteright} mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptation, and relationships with surrounding tissues with age and disease.",
keywords = "Adipogenesis, Adiponectin, Aging, Bone marrow adipocyte, Metabolism, Progenitor cells",
author = "Xiao Zhang and Hero Robles and Magee, {Kristann L.} and Lorenz, {Madelyn R.} and Zhaohua Wang and Charles Harris and Clarissa Craft and Scheller, {Erica L.}",
note = "Funding Information: This work was supported by grants from the National Institutes of Health including R00-DE02417 and startup funds from the Washington University Department of Medicine. We are also grateful for the core services provided by the Musculoskeletal Research Center (NIH P30-AR074992) and the Washington University Center for Cellular Imaging (supported by the Washington University School of Medicine, The Children{\textquoteright}s Discovery Institute of Washington University, and St. Louis Children{\textquoteright}s Hospital CDI-CORE-2015-505 and CDI-CORE-2019-813 and the Foundation for Barnes-Jewish Hospital 3770 and 4642). Lastly, we would like to extend special thanks to Dr. Jesse Procknow for technical assistance and to Dr. Steven Teitelbaum and Dr. Wei Zou for their helpful discussions during the initial stages of this project. Funding Information: This work was supported by grants from the National Institutes of Health including R00-DE02417 and startup funds from the Washington University Department of Medicine. We are also grateful for the core services provided by the Musculoskeletal Research Center (NIH P30-AR074992) and the Washington University Center for Cellular Imaging (supported by the Washington University School of Medicine, The Children?s Discovery Institute of Washington University, and St. Louis Children?s Hospital CDI-CORE-2015-505 and CDI-CORE-2019-813 and the Foundation for Barnes-Jewish Hospital 3770 and 4642). Lastly, we would like to extend special thanks to Dr. Jesse Procknow for technical assistance and to Dr. Steven Teitelbaum and Dr. Wei Zou for their helpful discussions during the initial stages of this project. Publisher Copyright: {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved.",
year = "2021",
month = aug,
doi = "10.7554/eLife.66275",
language = "English",
volume = "10",
journal = "eLife",
issn = "2050-084X",
}