A bioreducible polymer for efficient delivery of fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis

Min Suk Shim; Suk Ho Bhang; Kyunghwan Yoon; Kyunghee Choi; Younan Xia

doi:10.1002/anie.201206595

A bioreducible polymer for efficient delivery of fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis

Min Suk Shim, Suk Ho Bhang, Kyunghwan Yoon, Kyunghee Choi, Younan Xia

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.

Original language	English
Pages (from-to)	11899-11903
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	47
DOIs	https://doi.org/10.1002/anie.201206595
State	Published - Nov 19 2012

Keywords

RNA interference
intracellular delivery
nanoparticles
polymers
stem cells

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10.1002/anie.201206595

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abstract = "Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.",

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AU - Yoon, Kyunghwan

AU - Choi, Kyunghee

AU - Xia, Younan

PY - 2012/11/19

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KW - RNA interference

KW - intracellular delivery

KW - nanoparticles

KW - polymers

KW - stem cells

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ER -

A bioreducible polymer for efficient delivery of fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis

Abstract

Keywords

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