A bioreducible polymer for efficient delivery of fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis

Min Suk Shim, Suk Ho Bhang, Kyunghwan Yoon, Kyunghee Choi, Younan Xia

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.

Original languageEnglish
Pages (from-to)11899-11903
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number47
DOIs
StatePublished - Nov 19 2012

Keywords

  • RNA interference
  • intracellular delivery
  • nanoparticles
  • polymers
  • stem cells

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