Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.

Original languageEnglish
Pages (from-to)11899-11903
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number47
StatePublished - Nov 19 2012


  • RNA interference
  • intracellular delivery
  • nanoparticles
  • polymers
  • stem cells


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